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首页> 外文期刊>Venoms and Toxins >Comparative Protein Composition and Biological Effects Caused by Bothrops jararacussu and B. moojeni Crude Venoms
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Comparative Protein Composition and Biological Effects Caused by Bothrops jararacussu and B. moojeni Crude Venoms

机译：比较蛋白质成分和生物造成的影响具窍蝮蛇属jararacussu和B。moojeni粗毒液

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Background: The World Health Organization added snakebite envenoming to its priority list of neglected tropical diseases. Snakebite envenoming is a particularly important public health problem in rural areas of tropical and sub-tropical countries. In 2017, more than 30 thousand cases of snakebites were reported in Brazil, with the North and Northeast regions being the most affected and Bothrops sp snakes causing most of these cases. Objective: The objective of this study was to evaluate, in vitro, the coagulating, cytotoxic, oxidizing and antioxidant effects caused by Bothrops jararacussu and B. moojeni crude venoms. Methods: The crude venoms protein profiles were characterized, and the biological effects were evaluated and compared between the species. Results: The crude venoms composition showed similar protein profiles. The B. jararacussu and B. moojeni crude venoms showed coagulant activity and were capable of causing indirect hemolysis on the erythrocyte membrane, but did not protect the erythrocyte membrane from damage against hypotonic solutions. The B. jararacussu crude venom promoted hemagglutination. Conclusion: The crude venoms were not able to promote an oxidizing effect on hemoglobin and could not prevent the Phenylhydrazine oxidizing effect; however, the crude venoms presence caused increase in the methemoglobin formation by Phenylhydrazine oxidation.
机译：背景:世界卫生组织补充说蛇咬伤下毒的优先级列表被忽视的热带病。是一个特别重要的公共卫生问题在热带和亚热带的农村地区国家。在巴西的毒蛇咬伤事故报告,最北部和东北部地区影响和具窍蝮蛇属sp蛇造成的这些情况。研究旨在评估、体外凝结,细胞毒性、氧化和抗氧化作用由于具窍蝮蛇属jararacussu和b . moojeni粗糙的毒液。概要文件的特点,生物之间的影响进行评估和比较物种。显示出类似的蛋白质概要文件。jararacussu和b . moojeni原油毒液混凝剂活动,能够引起间接红细胞的溶血膜,但没有保护红血球膜损伤对低渗的解决方案。jararacussu粗毒液提升红血球凝聚。无法促进氧化作用吗血红蛋白并不能阻止苯肼氧化效果;粗毒液的存在增加引起的高铁血红蛋白形成由苯肼氧化。

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