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Scorpion Toxin-potassium Channel Interaction Law and its Applications

机译：蝎子Toxin-potassium通道交互法及其应用

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The scorpion toxins are the largest potassium channel-blocking, peptide family. The understanding of toxin binding interfaces is usually restricted to two classical binding interfaces: one is the toxin a-helix motif, and the other is the antiparallel B-sheet motif. In this review such traditional knowledge has been updated by another two different binding interfaces: one is BmKTX toxin using the rum motif between the a-helix and antiparallel B-sheet domains as the binding interface, while the other is Tsk toxin using the turn motif between the B-sheet in the N-terminal and a-helix domains as the binding interface. Their interaction analysis indicated that the scarce, negatively charged residues in the scorpion toxins played a critical role in orientating the toxin binding interface. In view of the toxin, being negatively charged amino acids as a "binding interface regulator", the law of scorpion toxin-potassium channel interaction was proposed, that is, the polymorphism of negatively charged residue distribution determines the diversity of toxin binding interfaces. Such a law was used to develop the scorpion toxin-potassium channel recognition control technique. According to this technique, three Kvl.3 channel-targeted peptides, using BmKTX as the template, were designed with the distinct binding interfaces from that of BmKTX by modulating the distribution of toxin, negatively charged residues. In view of the potassium channel as the common target of different animal toxins, the proposed law was also shown to adjust the binding interfaces of other animal toxins. The toxin-potassium channel interaction law would strongly accelerate the research and development of different potassium channel-blocking animal toxins in the future.
机译：蝎子毒素是最大的钾channel-blocking,肽的家庭。了解毒素绑定接口通常局限于两个经典的绑定接口:一个是一个螺旋图案的毒素,另一个是反平行的B-sheet主题。本文这样的传统知识由另一个两种不同的绑定更新接口:一个是用朗姆酒BmKTX毒素主题之间的一个螺旋和反平行的B-sheet域绑定接口,而另一种是啧啧毒素使用主题之间的B-sheet氨基和一个螺旋域名的绑定接口。交互作用分析表明,稀缺,蝎子的带负电荷的残留物毒素在定位中扮演了至关重要的作用毒素绑定接口。被带负电荷的氨基酸“绑定接口监管者”的法律蝎子toxin-potassium通道交互提出,负面的多态性残留分布决定了毒素的多样性绑定接口。被用来发展蝎子toxin-potassium通道识别控制技术。这种技术,三个Kvl.3 channel-targeted使用BmKTX作为模板,肽设计不同的绑定接口从BmKTX通过调制分布毒素,带负电荷的残留物。钾通道的共同目标不同的动物毒素,拟议的法律也显示调整的绑定接口其他动物毒素。互动法律强烈加速研究和开发不同的钾在未来channel-blocking动物毒素。

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