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首页> 外文期刊>Archives of neurology. >Natalizumab treatment in a patient with chronic inflammatory demyelinating polyneuropathy.
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Natalizumab treatment in a patient with chronic inflammatory demyelinating polyneuropathy.

机译：Natalizumab治疗与慢性病人炎性脱髓鞘多神经病。

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OBJECTIVE: To study clinical and paraclinical effects of natalizumab in a patient with chronic inflammatory demyelinating polyneuropathy (CIDP). DESIGN: Case report. SETTING: Department of Neurology, Heinrich-Heine University, Dusseldorf, Germany. Patient A patient with highly active CIDP who did not respond to standard therapies. Intervention Standard therapy then treatment with natalizumab (300 mg). MAIN OUTCOME MEASURES: Clinical disability, magnetic resonance imaging, and saturation of the alpha(4) integrin on T lymphocytes. RESULTS: T cells expressing the alpha(4) integrin were found in the inflamed peripheral nerve. Natalizumab bound with high affinity to the alpha(4) integrin on T lymphocytes in our patient. However, the patient's clinical condition deteriorated and as seen on magnetic resonance imaging without any measurable effect after treatment with this antibody. CONCLUSIONS: Although experimental evidence suggests that natalizumab could theoretically be effective in immune-mediated disorders of the peripheral nervous system, our patient with CIDP did not benefit from this therapeutic approach. Natalizumab cannot be recommended in CIDP at present and should only be explored in controlled clinical trials.
机译：目的:研究临床和paraclinicalnatalizumab在慢性患者的影响炎性脱髓鞘多神经病(CIDP)。设计:病例报告。神经学、海因里希·海涅大学、杜塞尔多夫、德国。CIDP谁没有回应记者的标准疗法。干预标准疗法治疗natalizumab(300毫克)。临床残疾,磁共振成像,和饱和度的α(4)整合素T淋巴细胞。α(4)整合素被发现在发炎周围神经。亲和力的α(4)整合素T淋巴细胞在我们的病人。当病人的临床状况恶化在没有任何磁共振成像治疗后可测量的影响抗体证据表明,natalizumab在免疫介导的理论上是有效的周围神经系统的障碍,我们的CIDP患者并没有从中受益治疗的方法。建议在CIDP目前只能探讨在临床试验控制。

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