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Connecting Leptin and Alzheimer Disease

机译：连接瘦素和阿尔茨海默病

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Alzheimer disease is the most common cause of late-life dementia and affects more than 35 million people worldwide and 5.5 million in the United States.1 Alzheimer disease is characterized by progressive loss of memory and cognition. Death typically occurs within 3 to 9 years after diagnosis. The major risk factor for Alzheimer disease is aging; therefore, the current demographics in developed countries with older populations portends dramatic increases in the number of cogni-tively impaired elderly persons. This poses an enormous burden on families, caregivers, and health care systems. The specific molecular pathogenesis of Alzheimer disease is still unresolved but studies suggest a major role of accumulation of misfolded proteins in the aging brain, which triggers oxidative and inflammatory damage, alteration in energy use, and synaptic dysfunction. Risk factors implicated in Alzheimer disease include midlife obesity and metabolic syndrome. The latter is associated with central (visceral) obesity, insulin resistance, type 2 diabetes, hyperlipidemia, hypertension, and increased cardiovascular risk.
机译：阿尔茨海默病是最常见的原因老年痴呆和影响超过35全世界数百万人,550万的美国提高阿尔茨海默病特点是进步的记忆和损失认知。年之后的诊断。阿尔茨海默病是老化;目前发达国家的人口老年人口预示着戏剧性的增加cogni-tively受损的老年人的数量人。家庭、护理人员和卫生保健系统。老年痴呆症的特定的分子发病机制疾病仍然悬而未决,但研究表明错误折叠的蛋白质积累的主要角色在大脑老化,引发氧化和炎症损伤,改变能源使用,和突触功能障碍。在阿尔茨海默病包括中年肥胖和代谢综合征。中央(内脏)肥胖、胰岛素抵抗,2型糖尿病、高脂血症、高血压、并增加心血管疾病的风险。

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