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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Expression of high mobility group box chromosomal protein-1 (HMGB-1) in gastric cancer.
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Expression of high mobility group box chromosomal protein-1 (HMGB-1) in gastric cancer.

机译：高迁移率族盒染色体蛋白1（HMGB-1）在胃癌中的表达。

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摘要

The intranuclear architectural protein termed high mobility group box chromosomal protein 1 (HMGB-1) has recently been identified as a potent proinflammatory mediator. The release of HMGB-1 results in the activation of macrophages and leads to an inflammatory response. In the tumor microenvironment, it is well known that there are local inflammatory reactions and the degree of inflammatory cell infiltration inside a tumor is correlated to the prognosis of the disease. In the present study, the expression of HMGB-1 in gastric cancer cells was evaluated in relation to the clinicopathological findings (n = 76), and its expression was analyzed in comparison to immune reactive cells in gastric cancer. The expression of HMGB-1 in gastric cancer cells with the intestinal type (90.7 positive cells per 200 cancer cells +/- 37.9, n = 40) was significantly increased compared to that in the diffuse type (56.8 +/- 32.7, n = 36) (p < 0.01). Secondly, HMGB-1 expression in gastric cancer cells was positively correlated with the degree of macrophage infiltration inside the tumor microenvironment (r = 0.869, p < 0.01). Thirdly, the prognosis of the low HMGB-1 group (n = 41) was significantly poorer than that of the high HMGB-1 group (n = 35, p < 0.05), although the HMGB-1 expression in cancer cells was not an independent prognostic factor. HMGB-1 expression may be one of the key factors regulating inflammatory reactions within the tumor microenvironment.
机译：近来，被称为高迁移率族盒染色体蛋白1（HMGB-1）的核内建筑蛋白被确定为有效的促炎介质。 HMGB-1的释放导致巨噬细胞活化，并导致炎症反应。在肿瘤微环境中，众所周知存在局部炎症反应，并且肿瘤内炎症细胞浸润的程度与疾病的预后相关。在本研究中，根据临床病理结果评估了胃癌细胞中HMGB-1的表达（n = 76），并与胃癌中的免疫反应性细胞进行了比较。 HMGB-1在肠型胃癌细胞中的表达（每200癌细胞中90.7阳性细胞+/- 37.9，n = 40）与弥漫型胃癌细胞中的HMGB-1表达（56.8 +/- 32.7，n = 36）（p <0.01）。其次，胃癌细胞中HMGB-1的表达与肿瘤微环境中巨噬细胞浸润的程度呈正相关（r = 0.869，p <0.01）。第三，低HMGB-1组（n = 41）的预后显着低于高HMGB-1组（n = 35，p <0.05），尽管癌细胞中HMGB-1表达并不高。独立的预后因素。 HMGB-1表达可能是调节肿瘤微环境中炎症反应的关键因素之一。

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