A role for DHX32 in regulating T-cell apoptosis.

Alli Z; Chen Y; Abdul-Wajid S; Al-Saud B; Abdelhaleem M

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A role for DHX32 in regulating T-cell apoptosis.

机译：DHX32在调节T细胞凋亡中的作用。

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DHX32 is a novel putative RNA helicase with an activation-dependent pattern of expression in T-cells. To gain insight into the role of DHX32, Jurkat-DHX32 cells, a stable Jurkat T-cell line with constitutive DHX32 expression, were generated by retroviral gene transfer. There were no significant differences between control and Jurkat-DHX32 cells in terms of proliferation and response to several chemotherapeutic agents. There was an altered response of Jurkat-DHX32 cells to Fas signaling associated with down-regulation of the anti-apoptotic protein c-FLIP short. In normal peripheral blood lymphocytes, a correlation between DHX32 and c-FLIP short expression was detected in response to different T-cell specific and non-specific activation stimuli. Our results suggest that DHX32 might be involved in regulating T-cell response to certain apoptotic stimuli.

机译：DHX32是一种新颖的推定RNA解旋酶，在T细胞中具有激活依赖性表达模式。为了深入了解DHX32的作用，通过逆转录病毒基因转移产生了Jurkat-DHX32细胞，该细胞是具有组成型DHX32表达的稳定Jurkat T细胞系。对照和Jurkat-DHX32细胞在增殖和对几种化学治疗剂的反应方面没有显着差异。 Jurkat-DHX32细胞对Fas信号的反应发生了改变，与抗凋亡蛋白c-FLIP short的下调有关。在正常的外周血淋巴细胞中，响应不同的T细胞特异性和非特异性激活刺激，检测到DHX32和c-FLIP短表达之间的相关性。我们的结果表明，DHX32可能参与调节T细胞对某些凋亡刺激的反应。

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《Anticancer Research: International Journal of Cancer Research and Treatment》 |2007年第1appa期|共5页
作者
Alli Z; Chen Y; Abdul-Wajid S; Al-Saud B; Abdelhaleem M;
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正文语种 eng
中图分类肿瘤学;
关键词
Apoptosis; DEAD-box RNA Helicases; T-Lymphocytes; 脱噬作用; T淋巴细胞;

机译：Apoptosis;DEAD-box RNA Helicases;T-Lymphocytes;脱噬作用;T淋巴细胞;

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1. A role for DHX32 in regulating T-cell apoptosis. [J] . Alli Z, Chen Y, Abdul-Wajid S, Anticancer Research: International Journal of Cancer Research and Treatment . 2007,第1Appa期

机译：DHX32在调节T细胞凋亡中的作用。
2. The role of CD95 in the regulation of peripheral T-cell apoptosis. [J] . Krueger A, Fas SC, Baumann S, Immunological reviews. . 2003,第0期

机译：CD95在调节周围T细胞凋亡中的作用。
3. DHX32 expression suggests a role in lymphocyte differentiation. [J] . Abdelhaleem M, Sun TH, Ho M Anticancer Research: International Journal of Cancer Research and Treatment . 2005,第4期

机译：DHX32表达表明在淋巴细胞分化中起作用。
4. CaMKII Mediates Angiotensin II-induced Cardiomyocytes Apoptosis. Role OF Ca~(2+), ROS and p38MAPK [C] . J. Palomeque, L. Sapia, C. Valverde, International Society for Heart Research . 2008

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6. Dual Role of miR-21 in CD4+ T-Cells: Activation-Induced miR-21 Supports Survival of Memory T-Cells and Regulates CCR7 Expression in Naive T-Cells [O] . Katarzyna Smigielska-Czepiel, Anke van den Berg, Pytrick Jellema, -1

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7. A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis. [O] . Halstead, JR, van Rheenen, J, Snel, MH, 2006

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8. Role of CXCR4 and Arrestins in Breast Cancer Signaling and Apoptosis. [R] . Wagener, B. M. 2006

机译：CXCR4和arrestins在乳腺癌信号转导和细胞凋亡中的作用。

A role for DHX32 in regulating T-cell apoptosis.

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