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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Retinoic acid modulates RAR alpha and RAR beta receptors in human glioma cell lines.
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Retinoic acid modulates RAR alpha and RAR beta receptors in human glioma cell lines.

机译：维甲酸可调节人神经胶质瘤细胞系中的RARα和RARβ受体。

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摘要

To identify retinoic acid (RA) signalling pathways involved in growth and differentiation in cells of the glial lineage, two human glioma ceh lines were studied. The three RA receptors (RARs) mRNAs were constitutively expressed, and of the three RXRs, RXR beta appeared predominant. Western blotting analysis confirmed the constitutive expression of RAR alpha and RAR beta. Treatment with all-trans-RA induced morphological changes in the two cell lines, which progressed from their normal pattern of randomly oriented spindle-shaped cells to fibroblast-like glial cells. RA up-regulated RAR alpha and RAR beta mRNAs in both cell lines. Interestingly, RA treatment up-regulated RAR beta proteins but not RAR alpha proteins, suggesting post-transcriptional regulations of RAR transcripts in glioma cells.
机译：为了确定与胶质谱系细胞的生长和分化有关的视黄酸（RA）信号通路，研究了两种人类神经胶质瘤ceh系。三个RA受体（RARs）mRNA组成型表达，在三个RXR中，RXR beta占主导。 Western印迹分析证实了RARα和RARβ的组成型表达。全反式RA的治疗诱导了这两种细胞系的形态变化，从正常的随机定向纺锤形细胞发展为成纤维样胶质细胞。 RA在两种细胞系中上调RAR alpha和RAR beta mRNA。有趣的是，RA治疗上调了RARβ蛋白而不是RARα蛋白，这提示神经胶质瘤细胞中RAR转录本的转录后调控。

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