Overexpression of polycomb protein BMI-1 in human specimens of breast, ovarian, endometrial and cervical cancer.

Honig A; Weidler C; Hausler S; Krockenberger M; Buchholz S; Koster F; Segerer SE; Dietl J; Engel JB

首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Overexpression of polycomb protein BMI-1 in human specimens of breast, ovarian, endometrial and cervical cancer.

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Overexpression of polycomb protein BMI-1 in human specimens of breast, ovarian, endometrial and cervical cancer.

机译：在乳腺癌，卵巢癌，子宫内膜癌和宫颈癌的人类标本中，多梳蛋白BMI-1的过表达。

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INTRODUCTION: The polycomb group (PcG) proteins form chromatin-modifying complexes that are commonly deregulated in cancer. The PcG protein BMI-I is overexpressed by various tumours and thus may contribute to malignant transformation. The current study investigated the expression of BMI-I in human specimens of breast, ovarian, endometrial and cervical cancer. MATERIALS AND METHODS: Expression of BMI-I was evaluated in human ovarian cancer samples by Western blot analysis and immunohistochemistry (IHC) and compared to healthy ovarian tissue. BMI-I expression in human specimens of breast, endometrial and cervical cancer was evaluated by IHC and then compared with the respective benign tissues. RESULTS: BMI-I was significantly (p<0.05) overexpressed in human breast, ovarian, endometrial and cervical cancer specimens as compared to benign controls. BMI-I expression was also more pronounced in the ovarian cancer samples as demonstrated by Western blot analysis. In human breast cancer samples, BMI-I expression was most pronounced in the invasion front of the tumour. CONCLUSION: The current study showed for the first time that the BMI-I protein is significantly overexpressed in ovarian, endometrial and cervical cancer and may thus be a potential target for novel antitumor therapies.

机译：简介：多梳基团（PcG）蛋白形成了染色质修饰复合物，通常在癌症中被解除调节。 PcG蛋白BMI-1被各种肿瘤过度表达，因此可能有助于恶性转化。当前的研究调查了BMI-I在乳腺癌，卵巢癌，子宫内膜癌和宫颈癌的人类标本中的表达。材料与方法：通过蛋白质印迹分析和免疫组织化学（IHC）评估了人卵巢癌样品中BMI-1的表达，并与健康的卵巢组织进行了比较。通过IHC评估了在乳腺癌，子宫内膜癌和宫颈癌的人类标本中的BMI-1表达，然后将其与各自的良性组织进行了比较。结果：与良性对照相比，BMI-1在人乳腺癌，卵巢癌，子宫内膜癌和宫颈癌标本中显着过表达（p <0.05）。如蛋白质印迹分析所证实，在卵巢癌样品中BMI-1表达也更明显。在人乳腺癌样品中，BMI-1表达在肿瘤的侵袭前沿最为明显。结论：目前的研究首次表明，BMI-1蛋白在卵巢癌，子宫内膜癌和宫颈癌中显着过表达，因此可能成为新型抗肿瘤治疗的潜在靶标。

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《Anticancer Research: International Journal of Cancer Research and Treatment》 |2010年第5期|共6页
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Honig A; Weidler C; Hausler S; Krockenberger M; Buchholz S; Koster F; Segerer SE; Dietl J; Engel JB;
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1. Overexpression of polycomb protein BMI-1 in human specimens of breast, ovarian, endometrial and cervical cancer. [J] . Honig A, Weidler C, Hausler S, Anticancer Research: International Journal of Cancer Research and Treatment . 2010,第5期

机译：在乳腺癌，卵巢癌，子宫内膜癌和宫颈癌的人类标本中，多梳蛋白BMI-1的过表达。
2. Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer. [J] . Kim JH, Yoon SY, Jeong SH, The Breast : . 2004,第5期

机译：Bmi-1癌蛋白的过度表达与浸润性导管癌的腋窝淋巴结转移有关。
3. Adverse impact of a history of violence for women with breast, cervical, endometrial, or ovarian cancer. [J] . Modesitt SC, Gambrell AC, Cottrill HM, Obstetrics and Gynecology: Journal of the American College of Obstetricians and Gynecologists . 2006,第6期

机译：暴力史对乳腺癌，宫颈癌，子宫内膜癌或卵巢癌妇女的不利影响。
4. Characterization of endogenous phosphorylation in p130Cas, an anti-estrogen resistance generating protein in human breast cancer. [C] . Giuseppe Infusini, Anthony Makkinje, David H. Perlman, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：P130CAs中内源性磷酸化的表征，人乳腺癌中抗雌激素产生蛋白质。
5. The regulation of p16 expression by the polycomb-group protein BMI-1 in primary human keratinocytes [D] . Kligys, Kristina. 2004

机译：聚梳齿蛋白BMI-1在原代人角质形成细胞中对p16表达的调节
6. The role of polycomb group protein Bmi-1 and Notch4 in breast cancer stem cell inhibition by benzyl isothiocyanate [O] . Su-Hyeong Kim, Shivendra V. Singh -1

机译：聚梳基蛋白Bmi-1和Notch4在异硫氰酸苄酯抑制乳腺癌干细胞中的作用
7. Activator protein-2 overexpression accounts for increased insulin receptor expression in human breast cancer. [O] . Paonessa F., Foti D., Costa V., 2006

机译：激活蛋白-2过表达导致人乳腺癌中胰岛素受体表达增加。

Overexpression of polycomb protein BMI-1 in human specimens of breast, ovarian, endometrial and cervical cancer.

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