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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Cytokeratin 19 fragment/carcinoembryonic antigen ratio in pleural effusion is a useful marker for detecting malignant pleural mesothelioma.
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Cytokeratin 19 fragment/carcinoembryonic antigen ratio in pleural effusion is a useful marker for detecting malignant pleural mesothelioma.

机译：胸腔积液中细胞角蛋白19片段/癌胚抗原的比率是检测恶性胸膜间皮瘤的有用标志物。

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摘要

BACKGROUND: The clinical utility of tumour markers in pleural effusion is still controversial with regard to the efficient detection of malignant pleural mesothelioma (MPM). PATIENTS AND METHODS: The levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA 21-1) were retrospectively studied in pleural effusion of unknown origin in patients who had undergone medical thoracoscopy under local anaesthesia. RESULTS: The study included 134 patients (103 men and 31 women); among them, 33 had MPM. The level of pleural effusion CYFRA 21-1 and the CYFRA 21-1/CEA ratio were significantly different between MPM and other diseases (p<0.01). The sensitivity and specificity of the pleural effusion CYFRA 21-1/CEA ratio were 84.8% and 80.2%, respectively, when the CYFRA 21-1/CEA ratio cut-off value determined by receiver operating characteristic curve analysis was 19.1. CONCLUSION: MPM should be suspected when the CYFRA 21-1/CEA ratio in pleural effusion is greater than 19.1.
机译：背景：在有效检测恶性胸膜间皮瘤（MPM）方面，肿瘤标志物在胸腔积液中的临床应用仍存在争议。病人和方法：回顾性研究了在局部麻醉下进行了胸腔镜检查的患者中，未知来源的胸膜积液中癌胚抗原（CEA）和细胞角蛋白19片段（CYFRA 21-1）的水平。结果：该研究包括134名患者（103名男性和31名女性）;其中，有33个具有MPM。 MPM与其他疾病之间的胸腔积液CYFRA 21-1水平和CYFRA 21-1 / CEA比值存在显着差异（p <0.01）。当通过接受者工作特征曲线分析确定的CYFRA 21-1 / CEA比率的临界值是19.1时，胸腔积液CYFRA 21-1 / CEA比率的敏感性和特异性分别为84.8％和80.2％。结论：当胸腔积液中CYFRA 21-1 / CEA比值大于19.1时，应怀疑MPM。

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