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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Colorectal cancer and genetic polymorphism of DNA double-strand break repair gene XRCC4 in Taiwan.
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Colorectal cancer and genetic polymorphism of DNA double-strand break repair gene XRCC4 in Taiwan.

机译：台湾地区的大肠癌和DNA双链断裂修复基因XRCC4的遗传多态性。

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摘要

The DNA repair gene X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4) is thought to play a major role in the caretaking of the whole genome via double-strand break repair. However, the association of polymorphic variants of XRCC4 with colorectal cancer susceptibility has never been reported. In this hospital-based case-control study, the association of XRCC4 polymorphisms C-1622T (rs7727691), G-1394T (rs6869366), G-652T (rs2075685), C-571T (rs2075686), intron 3 DIP (rs28360071), S247A (rs3734091) and intron 7 DIP (rs28360317) with colorectal cancer risk in a Taiwanese population was investigated. The genotypes of XRCC4 of 370 patients with colorectal cancer and 370 age- and gender-matched healthy controls were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. We found significant differences in the genetic and allelic frequencies of the XRCC4 G-1394T between the colorectal cancer and control groups (p=0.0003 and 8.32 x 10(-5), respectively). The distributions of other genetic polymorphisms between cases and the control group were not significantly different. We conclude that the G allele of XRCC4 G-1394T may contribute to colorectal carcinogenesis and may be useful for early detection of colorectal cancer.
机译：DNA修复基因X射线修复补充了中国仓鼠细胞4（XRCC4）的缺陷修复，通过双链断裂修复在整个基因组的照护中起着重要作用。然而，从未报道过XRCC4的多态性变体与大肠癌易感性的关系。在这项基于医院的病例对照研究中，XRCC4多态性C-1622T（rs7727691），G-1394T（rs6869366），G-652T（rs2075685），C-571T（rs2075686），内含子3 DIP（rs28360071），调查了台湾人群中具有大肠癌风险的S247A（rs3734091）和内含子7 DIP（rs28360317）。通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析确定了370例大肠癌和370例年龄和性别匹配的健康对照者的XRCC4基因型。我们发现大肠癌和对照组之间XRCC4 G-1394T的遗传和等位基因频率存在显着差异（分别为p = 0.0003和8.32 x 10（-5））。病例与对照组之间其他遗传多态性的分布无明显差异。我们得出结论，XRCC4 G-1394T的G等位基因可能有助于结直肠癌的发生，并且可能对早期检测结直肠癌有用。

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