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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >CpG island promoter methylation (CIHM) status of tumor suppressor genes correlates with morphological appearances of gastric cancer.
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CpG island promoter methylation (CIHM) status of tumor suppressor genes correlates with morphological appearances of gastric cancer.

机译：抑癌基因的CpG岛启动子甲基化（CIHM）状态与胃癌的形态学表现相关。

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摘要

CpG island hypermethylation (CIHM) of tumor suppressor genes is one of the major events in the gastric carcinogenesis. We aimed to investigate the association between CIHM status of tumor suppressor genes and clinicopathological and morphological characteristics of gastric cancer. PATIENTS AND METHODS: CIHM of p14, p16, Death-associated protein kinase (DAPK) and E-cadherin (CDH1) genes were determined by methylation-specific-polymerase chain Reaction in 146 gastric cancer tissues. CIHM-high was defined as three or more methylated CpG islands. RESULTS: CIHM pf p14 was found in 70 (47.9%) cases, in 26 (17.8%) for p16, in 104 (71.2%) for CDH1 and in 127 (87.0%) for DAPK. CIHM-high was also found in 63 cases (43.2%). No association was found between between CIHM status and different staging, Lauren's subtypes, anatomic location, venous and lymphatic invasion, lymph node metastasis, distant metastasis, or peritoneal dissemination. However, among early gastric cancer cases, the depressed type with ulceration presented a significantly lower prevalence of CIHM of DAPK. In addition, Borrmann type IV cases presented significantly lower prevalence of CIHM-high among advanced gastric cancer. The Borrmann type IV cases also presented lower mean methylation number. CONCLUSION: The present results suggest that CIHM of DAPK and CIHM-high were associated with the morphological appearance of depressed type with ulceration in early gastric cancer, and Borrmann type IV advanced gastric cancer, respectively.
机译：肿瘤抑制基因的CpG岛超甲基化（CIHM）是胃癌发生中的主要事件之一。我们旨在调查肿瘤抑制基因的CIHM状态与胃癌临床病理和形态特征之间的关系。病人与方法：通过甲基化特异性聚合酶链反应法在146例胃癌组织中测定了p14，p16，死亡相关蛋白激酶（DAPK）和E-钙粘蛋白（CDH1）基因的CIHM。高CIHM被定义为三个或多个甲基化的CpG岛。结果：CIHM pf p14发现70例（47.9％），p16发生26例（17.8％），CDH1发生104例（71.2％），DAPK发生127例（87.0％）。在63例中也发现CIHM高（43.2％）。在CIHM状态与不同分期，Lauren的亚型，解剖位置，静脉和淋巴管浸润，淋巴结转移，远处转移或腹膜扩散之间未发现关联。但是，在早期胃癌病例中，伴有溃疡的抑郁型患者的DAPK CIHM患病率明显较低。此外，在晚期胃癌中，IV型Borrmann病例的CIHM高发生率明显较低。 Borrmann IV型病例的平均甲基化数也较低。结论：目前的结果表明，DAPK和CIHM-high与早期胃癌和Borrmann IV型晚期胃癌的抑郁症伴溃疡的形态学表现有关。

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