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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Frequent absence of tumor suppressor FUS1 protein expression in human bone and soft tissue sarcomas.
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Frequent absence of tumor suppressor FUS1 protein expression in human bone and soft tissue sarcomas.

机译：在人的骨骼和软组织肉瘤中经常缺少肿瘤抑制因子FUS1蛋白的表达。

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摘要

BACKGROUND: FUS1 is a tumor suppressor gene located on human chromosome 3p21.3. Frequent loss of FUS1 protein expression is associated with lung cancer development. This study examined FUS1 expression and its possible tumor-suppressive role in bone and soft tissue sarcomas. MATERIALS AND METHODS: The expressions of FUS1 mRNA and FUS1 protein were assessed in sarcoma cell lines, sarcoma tissues, benign bone and soft-tissue tumor (BST) tissues, and healthy tissues. Exogenous FUS1 gene transfection was performed on sarcoma cell lines. RESULTS: FUS1 mRNA expression was detected in all sarcoma cell lines, all benign BSTs and healthy tissues, and almost all sarcoma tissues. In contrast, FUS1 protein expression was frequently lost in sarcoma cells and sarcoma tissues. The exogenous FUS1 gene delivery induced strong FUS1 protein expression, inhibition of cell viability and apoptosis in sarcoma cells. CONCLUSION: FUS1 may act as a tumor suppressor in bone and soft-tissue sarcomas.
机译：背景：FUS1是位于人类3p21.3染色体上的抑癌基因。 FUS1蛋白表达的频繁丢失与肺癌的发展有关。这项研究检查了FUS1表达及其在骨和软组织肉瘤中可能的肿瘤抑制作用。材料与方法：观察肉瘤细胞系，肉瘤组织，良性骨和软组织肿瘤（BST）组织以及健康组织中FUS1 mRNA和FUS1蛋白的表达。在肉瘤细胞系上进行外源性FUS1基因转染。结果：在所有肉瘤细胞系，所有良性BSTs和健康组织以及几乎所有肉瘤组织中均检测到FUS1 mRNA表达。相反，FUS1蛋白表达在肉瘤细胞和肉瘤组织中经常丢失。外源性FUS1基因传递诱导强烈的FUS1蛋白表达，抑制肉瘤细胞的生存能力和凋亡。结论：FUS1可能在骨和软组织肉瘤中起抑癌作用。

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