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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Impact of renal failure on the tumor markers of mesothelioma, N-ERC/mesothelin and osteopontin.
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Impact of renal failure on the tumor markers of mesothelioma, N-ERC/mesothelin and osteopontin.

机译：肾衰竭对间皮瘤，N-ERC /间皮素和骨桥蛋白的肿瘤标志物的影响。

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BACKGROUND: Knowledge of the characteristics and effective use of tumour markers for mesothelioma is essential for early-stage diagnosis of mesothelioma. We examined whether renal dysfunction influences blood concentrations of promising new tumour markers, N-ERC/mesothelin (N-ERC) and osteopontin (OPN), to an important degree. PATIENTS AND METHODS: Levels of serum N-ERC and plasma OPN in 32 patients with chronic renal dysfunction, 22 of whom were on hemodialysis (CKD group), and 102 healthy volunteers were measured. RESULTS: Serum concentrations of N-ERC and plasma concentrations of OPN in the CKD group were significantly higher than those in volunteers, regardless of diabetes status and age. Blood concentrations of these markers increased as renal function decreased. CONCLUSION: N-ERC and OPN concentrations are significantly influenced by renal function. Therefore, the extent of renal failure must be considered when inferring the existence of tumours and chemotherapeutic response from the values of these markers in routine practice.
机译：背景：了解间皮瘤的特征和肿瘤标志物的有效使用对于间皮瘤的早期诊断至关重要。我们检查了肾功能不全是否在重要程度上影响了有前途的新肿瘤标志物N-ERC /间皮素（N-ERC）和骨桥蛋白（OPN）的血药浓度。患者和方法：测量32例慢性肾功能不全患者的血清N-ERC和血浆OPN水平，其中22例接受血液透析（CKD组），并测量102名健康志愿者。结果：CKD组的血清N-ERC浓度和OPN血浆浓度均显着高于志愿者，而与糖尿病状况和年龄无关。这些标记物的血液浓度随肾功能下降而增加。结论：N-ERC和OPN浓度受肾脏功能的显着影响。因此，在常规实践中从这些标志物的值推断出肿瘤的存在和化疗反应时，必须考虑肾功能衰竭的程度。

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