...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Latent forms of transforming growth factor-beta 2 (TGF-beta 2) in breast cyst fluid.
【24h】

Latent forms of transforming growth factor-beta 2 (TGF-beta 2) in breast cyst fluid.

机译：乳腺囊肿液中潜在的转化生长因子-β2（TGF-β2）形式。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Transforming growth factor-beta (TGF-beta) is secreted by cells in high molecular weight, latent forms and the in vivo mechanisms for the activation remain largely an enigma. Women who have palpable breast cyst with intracystic Na/K < 3 may have a higher risk of developing breast cancer than those with intracystic Na/K > 3. Finding of significantly higher concentrations of TGF-beta 2 in the Na/K > 3 group than Na/K < 3 group may explain the lower risk of breast cancer in the Na/K > 3 group. The aim of the present study was to characterise the latent forms of TGF-beta 2 in breast cyst fluid using HPLC, affinity chromatography, SDS-PAGE and immunostaining techniques. We found that TGF-beta 2 is present in high molecular weight, latent forms in breast cyst fluid: as a complex, probably with alpha 2-macroglobulin and a 56 kD protein which is likely to be a precursor form of TGF-beta 2.
机译：转化生长因子-β（TGF-β）以高分子量，潜在形式被细胞分泌，并且激活的体内机制在很大程度上仍是一个谜。囊内Na / K <3的可触及乳腺囊肿的妇女比囊内Na / K> 3的妇女患乳腺癌的风险更高。在Na / K> 3组中发现TGF-beta 2的浓度明显更高比Na / K <3组要高，这可能解释了Na / K> 3组患乳腺癌的风险较低。本研究的目的是使用HPLC，亲和色谱，SDS-PAGE和免疫染色技术表征乳腺囊肿液中TGF-β2的潜在形式。我们发现TGF-beta 2以高分子量，潜伏形式存在于乳腺囊肿液中：作为复合物，可能与α2-巨球蛋白和56 kD蛋白（可能是TGF-beta 2的前体形式）结合在一起。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号