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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Different human papillomavirus genotypes in ano-genital lesions.
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Different human papillomavirus genotypes in ano-genital lesions.

机译：肛门生殖器病变中的不同人乳头瘤病毒基因型。

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摘要

In order to verify the frequency and physical state of some viral strains of Human Papillomavirus (HPV) in anogenital lesions, two-hundred and four specimens were studied. HPV/DNA was detected by using non isotopic in situ hybridization method, HPV-DNA was found in 25 lesions. The integrated pattern of HPV types 16/18 was found only in invasive carcinomas, the episomic one in all high risk lesions, never in invasive carcinomas. The low oncogenic risk genotypes 6/11 were detected only in condylomata acuminata, the high oncogenic risk genotypes 16/18 were found not only in cervical intraepithelial and invasive lesions, but also in a condyloma acuminatum. Our findings confirm the importance of the viral genotypes in the evaluation of the risk for malignancy. Therefore, the detection of a high risk viral genotype, independently of its physical state, can evoke the ghost of the malignancy also in a low risk cervical lesion.
机译：为了验证生殖器病变中人类乳头瘤病毒（HPV）某些病毒株的频率和物理状态，研究了200和4个标本。采用非同位素原位杂交技术检测HPV / DNA，在25个病灶中发现HPV-DNA。 HPV 16/18型的整合模式仅在浸润性癌中发现，在所有高风险病变中都是流行的，而在浸润性癌中则没有。仅在尖锐湿疣中检测到低致癌风险基因型6/11，不仅在宫颈上皮内和浸润性病变中发现高致癌风险基因型16/18，而且在尖锐湿疣中也发现了高致癌风险基因型。我们的发现证实了病毒基因型在评估恶性肿瘤风险中的重要性。因此，高风险病毒基因型的检测，无论其物理状态如何，都可以在低风险宫颈病变中引起恶性肿瘤。

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