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首页> 外文期刊>Psychology of addictive behaviors >Anhedonia as a Phenotypic Marker of Familial Transmission of Polysubstance Use Trajectories Across Midadolescence
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Anhedonia as a Phenotypic Marker of Familial Transmission of Polysubstance Use Trajectories Across Midadolescence

机译：快感缺乏作为一个家族的表型标记多重药物使用的传播轨迹在Midadolescence

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Psychopathologic traits that arise in adolescence may increase proneness to substance use uptake as well as channel the familial transmission of substance use. Poly use is a common pattern of substance use in youth. To identify a parsimonious model of familial transmission of substance use, the current study tested whether anhedonia-a psychopathologic endophenotype manifested as the inability to experience pleasure-mediates the association of family history of substance use (FHS) with polysubstance use patterns across midadolescence. High school students (N = 3,392) in Los Angeles, CA, completed 4 semiannual surveys of mental health and substance use from ages 14-to 16-years-old. Use and co-use of cigarettes, alcohol, and marijuana across the 4 waves were reduced to 4 homogenous classes using parallel process growth mixture modeling: (a) abstainers (N = 1,629, 48.0%); (b) experimenters (N = 1,293, 38.1%); (c) polysubstance using marijuana escalators (N = 210, 6.2%); and (d) heavy polysubstance using cigarette escalators (N = 126, 3.7%). FHS was positively associated with membership in each of the three substance using trajectory groups (vs. the abstainers group). After adjusting for depressive symptoms and other covariates, associations of FHS with membership in the polysubstance using marijuana escalators group and with the heavy polysubstance using cigarette escalators group (in comparison with the abstainers or experimenters groups) were each significantly mediated by anhedonia in youth age 14 (the proportion mediated by anhedonia: 0.33-0.42). Etiology research and intervention addressing anhedonia may have value for understanding and preventing the familial transmission of adolescent polysubstance use patterns.
机译：Psychopathologic特征出现在青春期可以增加倾向物质使用吸收吗通道的家族性传播物质的使用。物质使用在青年。吝啬的家族的传播模型物质使用,当前的研究测试了anhedonia-a psychopathologic表型表现为无法体验pleasure-mediates协会的家庭物质使用(FHS)和多重药物的历史在midadolescence使用模式。学生在洛杉矶(N = 3392)、钙、完成4半年度调查的精神健康和物质使用的年龄在14到16岁。使用和co-use香烟、酒精和大麻在4波被减少到4同质类使用并行过程的增长混合建模:(a)戒酒者(N = 1629,48.0%);多重药物使用大麻自动扶梯(N =210年,6.2%);香烟自动扶梯(N = 126, 3.7%)。积极与会员的联系在一起三个物质使用轨迹组(vs。饮酒组)。抑郁症状和其他,FHS协会的会员多重药物使用大麻自动扶梯和沉重的多重药物使用香烟自动扶梯(相比戒酒者或实验者组)快感缺乏显著的青年时代14(由快感缺乏比例:0.33 - -0.42)。解决快感缺乏可能值理解和防止家族青少年多重药物使用的传播模式。

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