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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >The relevance of weight loss for survival and quality of life in patients with advanced gastrointestinal cancer treated with palliative chemotherapy.
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The relevance of weight loss for survival and quality of life in patients with advanced gastrointestinal cancer treated with palliative chemotherapy.

机译：姑息化疗治疗晚期胃肠道癌患者体重减轻与生存和生活质量的相关性。

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摘要

BACKGROUND: Chemotherapy is frequently used for palliation in patients with advanced gastrointestinal (GI) cancer and improvements in quality of life (QoL) and survival are documented. Several pre-treatment factors, particularly poor performance status, influence the outcomes. The relative importance of nutrition-associated factors is less well known. PATIENTS AND METHODS: Data from 152 patients treated within four randomised studies were analysed to explore the relations between weight loss, nutrition-associated parameters, performance status, response to chemotherapy, global QoL and survival. RESULTS: Patients with weight loss, poor performance, higher frequency of nutritional problems and low haemoglobin levels had a lower probability of responding to treatment. Global QoL was decreased in patients having weight loss as well as problems with pain or fatigue. Diagnosis had the strongest association to survival. In a multivariate analysis poor performance and weight loss were also independently related to survival. CONCLUSION: Weight loss and several nutrition-associated problems were associated with lower QoL, less likelihood to respond to chemotherapy and poor survival.
机译：背景：化学疗法经常用于晚期胃肠道（GI）癌症患者的缓解，并记录了生活质量（QoL）和存活率的改善。几种预处理因素，尤其是不良的表现状态，会影响结果。营养相关因素的相对重要性尚不清楚。患者与方法：分析了四项随机研究中治疗的152例患者的数据，以探索体重减轻，营养相关参数，表现状态，对化疗的反应，总体QoL和生存率之间的关系。结果：体重减轻，机能不佳，营养问题发生频率较高和血红蛋白水平低的患者对治疗反应的可能性较低。体重减轻以及疼痛或疲劳问题的患者的总体QoL降低。诊断与生存最密切相关。在多变量分析中，不良的表现和体重减轻也与生存率独立相关。结论：体重减轻和一些与营养相关的问题与QoL降低，对化学疗法的反应可能性降低和生存期差有关。

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