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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Association of COMT haplotypes and breast cancer risk in caucasian women.
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Association of COMT haplotypes and breast cancer risk in caucasian women.

机译：白人女性中COMT单倍型与乳腺癌风险的关联。

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摘要

Catechol-O-methyl transferase (COMT) is an important estrogen-metabolizing enzyme, and common genetic variants in this gene could affect breast cancer risk. We conducted a large population-based case control study in Massachusetts, New Hampshire, and Wisconsin to examine six strategically selected COMT haplotype-tagging (ht) single nucleotide polymorphism (SNPs), including the val158met polymorphism (rs4680), in relation to breast cancer risk. Analyses were based on 1,655 Caucasian women with invasive breast cancer and 1,470 Caucasian controls. None of the six individual SNPs were associated with breast cancer risk. The global test for haplotype associations was nonsignificant (p-value=0.097), although two uncommon haplotypes present in 6% of the study population showed statistically significant inverse associations with risk. These results suggest that genetic variation in COMT has no significant association with breast cancer risk among Caucasian women.
机译：儿茶酚-O-甲基转移酶（COMT）是一种重要的雌激素代谢酶，该基因的常见遗传变异可能会影响乳腺癌的风险。我们在马萨诸塞州，新罕布什尔州和威斯康星州进行了基于人群的大型病例对照研究，以研究与乳腺癌相关的六个战略选择的COMT单倍型标签（ht）单核苷酸多态性（SNP），包括val158met多态性（rs4680）风险。分析是基于1,655名患有浸润性乳腺癌的白人妇女和1,470名白人控制的。六个单独的SNP均与乳腺癌风险无关。尽管在6％的研究人群中存在两种不常见的单倍型，但与风险之间存在统计学上的显着负相关，但对单倍型关联的全球检验没有显着意义（p值= 0.097）。这些结果表明，COMT的遗传变异与白人女性之间的乳腺癌风险没有显着相关性。

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