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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Nonadherence to imatinib treatment in patients with gastrointestinal stromal tumors: the ADAGIO study.
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Nonadherence to imatinib treatment in patients with gastrointestinal stromal tumors: the ADAGIO study.

机译：胃肠道间质瘤患者对伊马替尼治疗的不依从性：ADAGIO研究。

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摘要

AIM: To determine imatinib nonadherence rates in patients with gastrointestinal tumors (GIST) over 90 days. PATIENTS AND METHODS: A prospective 90-day observational, open-label, multicenter study was carried out of 28 evaluable GIST patients on imatinib. Nonadherence behavior was measured using a 4-item patient interview. Clinicians, patients, and collaterals rated perceived patient adherence on a 0-100 VAS scale. RESULTS: Nonadherence rates in the 4 weeks prior to baseline and follow-up were 29% (95% CI=26-32) and 24% (95% CI=21-27, p>0.05). Mean VAS ratings of perceived adherence ranged from 95.2 +/- 10.2 to 97.3 +/- 4.8 (p>0.05 for time and source of rating). Correlations between perceptions of and actual adherence behavior were negative. CONCLUSION: In this first study on imatinib nonadherence in GIST patients, rates were similar to those observed in patients with chronic myeloid leukemia, higher than clinically expected and exceeding meta-analytic estimates for cancer. Nonadherence rates were consistent across the 90-day period. Nonadherence behavior should be assessed by clinicians.
机译：目的：确定90天内胃肠道肿瘤（GIST）患者的伊马替尼非依从率。患者和方法：对28位伊马替尼可评估的GIST患者进行了为期90天的观察性开放标签多中心前瞻性研究。使用4项患者访谈来衡量不粘连行为。临床医生，患者和抵押品以0-100 VAS量表对患者的依从性进行评分。结果：基线和随访前4周的不依从率分别为29％（95％CI = 26-32）和24％（95％CI = 21-27，p> 0.05）。知觉依从性的平均VAS评分范围为95.2 +/- 10.2至97.3 +/- 4.8（评分时间和评分来源为p> 0.05）。认知与实际依从行为之间的相关性为负。结论：在这项关于GIST患者伊马替尼不依从性的首次研究中，其发生率与慢性粒细胞白血病患者相似，高于临床预期且超过了荟萃分析的癌症估计值。在90天内，不遵守率保持一致。不依从行为应由临床医生评估。

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