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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Black sheep among the flock of protein structures
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Black sheep among the flock of protein structures

机译：害群之马在群蛋白质结构

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摘要

The recent announcement made by the University of Alabama at Birmingham (USA) that a number of crystal structures produced in the laboratory of Dr H. M. Krishna Murthy will have to be removed from the Protein Data Bank and retracted from the literature, spread a Shockwave among the macromolecular crystallography community. These structures were published over a period of seven years (1999-2006), and included such important proteins as dengue virus protease (1bep, 1df9, 2qid), complement component proteins (2hr0, 1g40, 1g44), vaccinia complement proteins (1rid, 1y8e), apolipoproteins (1i61, 2ou1, 2a01), and Taq DNA polymerase (1cmw, 1bgx). In the past there have been cases in which structures determined by X-ray crystallography have had to be retracted because of errors in data interpretation or in the programs utilized in structure solution. These are understandable, as mistakes do occur. This time, however, it appears that the retracted structures were deliberately fabricated and there is no evidence that any experimental data were actually collected.
机译：大学最近宣布由在伯明翰阿拉巴马州(美国)的数量的实验室生产的晶体结构h . m .克里希纳博士没吃将会被删除从蛋白质数据银行和收回文学传播的冲击波大分子晶体学社区。结构被刊登在一段7年(1999 - 2006),包括这样的重要蛋白质作为登革热病毒蛋白酶(1 cep 1 df9,2 qid),蛋白质补充组件(2 hr0 1 g40,1 g44),牛痘补充蛋白质(1去掉,1 y8e),载脂蛋白(1 i61 2 ou1 2 a01),和Taq DNA聚合酶(1小王,1 bgx)。在案件中,结构所决定的x射线晶体学必须收回因为错误的数据或解释项目利用结构的解决方案。这些都是可以理解的,因为错误发生。然而,这一次,看来收回结构被故意捏造的没有证据表明任何实验数据吗实际上收集。

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