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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Expression of mucin-1, galectin-1 and galectin-3 in human leiomyosarcoma in comparison to leiomyoma and myometrium.
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Expression of mucin-1, galectin-1 and galectin-3 in human leiomyosarcoma in comparison to leiomyoma and myometrium.

机译：与平滑肌瘤和子宫肌层相比，黏蛋白-1，半乳凝素-1和半乳凝素-3在人平滑肌肉瘤中的表达。

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BACKGROUND: The potential mechanism of malignant transformation from leiomyoma to leiomyosarcoma is still debated. The aim was the evaluation of expression patterns of mucin-1 (MUC1) (MUC1 VU-4-H5), galectin-1 (Gal-1) and galectin-3 (Gal-3) in human myometrium and leiomyoma and in comparison to leiomyosarcoma. MATERIALS AND METHODS: Myometrium, leiomyoma and leiomyosarcoma tissues were obtained from 79 patients. Samples were analyzed regarding the expression of MUC1, Gal-1 and Gal-3 by immunohistochemical staining of paraffin-embedded material. RESULTS: The expression of MUC1 (VU4-H5) was up-regulated in leiomyoma (p = 0.065) and leiomyosarcoma (p = 0.039) as compared to the myometrium. In contrast, there were no significant differences in expression of Gal-3 in the tissues from the myometrium, myoma and leiomyosarcoma. Concerning Gal-1 expression, the differences were not significant comparing myometrium and leiomyosarcoma (p = 0.277). Myoma had elevated levels of Gal-1 compared to myometrium (p = 0.007) and leiomyosarcoma (p < 0.0001). CONCLUSION: MUC1 and Gal-1 might be useful for evaluating the potential of leiomyoma to transform into leiomyosarcoma and, therefore, help in risk-adapted consultation and adjusted treatment.
机译：背景：从平滑肌瘤到平滑肌肉瘤的恶性转化的潜在机制仍存在争议。目的是评估粘蛋白-1（MUC1）（MUC1 VU-4-H5），半乳凝素-1（Gal-1）和半乳凝素-3（Gal-3）在人子宫肌层和平滑肌瘤中的表达模式，并与之比较平滑肌肉瘤。材料与方法：取自79例患者的子宫肌层，平滑肌瘤和平滑肌肉瘤组织。通过石蜡包埋材料的免疫组织化学染色分析了有关MUC1，Gal-1和Gal-3表达的样品。结果：与肌层相比，平滑肌瘤（p = 0.065）和平滑肌肉瘤（p = 0.039）中MUC1（VU4-H5）的表达上调。相反，在子宫肌层，肌瘤和平滑肌肉瘤的组织中，Gal-3的表达没有显着差异。关于Gal-1表达，比较子宫肌层和平滑肌肉瘤，差异不显着（p = 0.277）。与肌层（p = 0.007）和平滑肌肉瘤（p <0.0001）相比，肌瘤的Gal-1水平升高。结论：MUC1和Gal-1可能有助于评估平滑肌瘤转化为平滑肌肉瘤的可能性，因此有助于风险适应性咨询和调整治疗。

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