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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Direct-method SAD phasing of proteins enhanced by the use of intrinsic bimodal phase distributions in the subsequent phase-improvement process
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Direct-method SAD phasing of proteins enhanced by the use of intrinsic bimodal phase distributions in the subsequent phase-improvement process

机译：直接法的定相蛋白增强了使用内在的双峰分布阶段在随后的phase-improvement过程

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摘要

A modified SAD (single-wavelength anomalous diffraction) phasing algorithm has been introduced in the latest version of the program OASIS. In addition to direct-method phases and figures of merit, Hendrickson-Lattman coefficients that correspond to the original unresolved bimodal phase distributions are also output and used in subsequent phase-improvement procedures in combination with the improved phases. This provides the possibility of rebreaking the SAD phase ambiguity using the ever-improving phases resulting from the phase-improvement process. Tests using experimental SAD data from six known proteins showed that in all cases the new treatment produced significant improved results.
机译：修改后的悲伤(单波长反常衍射)逐步算法介绍了最新版本的程序绿洲。数据的价值,Hendrickson-Lattman系数,对应于原始未解决的双峰也相分布在随后的phase-improvement输出和使用结合改进的程序阶段。rebreaking悲伤阶段使用的模棱两可不断完善的阶段产生的phase-improvement过程。实验悲伤数据从六个已知的蛋白质显示,在所有情况下,新治疗产生显著改善的结果。

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