Structure of the major carrot allergen Dau c 1

Zora Markovic Housley; Arnaud Basle; Sivaraman PadavattanBernhard MadereggerTilman SchirmerKarin Hoffmann Sommergruber

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Structure of the major carrot allergen Dau c 1

机译：结构的主要胡萝卜过敏原道c 1

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摘要

Dau c 1 is a major allergen of carrot (Daucus carota) which displays IgE cross-reactivity with the homologous major birch-pollen allergen Bet v 1. The crystal structure of Dau c 1 has been determined to a resolution of 2.7 A, revealing tight dimers. The structure of Dau c 1 is similar to those of the major allergens from celery, Api g 1, and birch pollen, Bet v 1. Electron density has been observed in the hydrophobic cavity of each monomer and has been modelled with polyethylene glycol oligomers of varying length. Comparison of the surface topology and physicochemical properties of Dau c 1 and Bet v 1 revealed that they may have some, but not all, epitopes in common. This is in agreement with the observation that the majority of carrot-allergic patients have Bet v 1 cross-reactive IgE antibodies, whereas others have Dau c 1-specific IgE antibodies which do not recognize Bet v 1.

机译：道c 1是一个胡萝卜(胡萝卜属的主要过敏原胡萝卜),显示IgE大同源大桦树花粉过敏原Bet v1. 决心分辨率为2.7,发人深省严格的二聚体。从芹菜的主要过敏原,Apig - 1,和桦树花粉,Bet v 1。已经观察到的疏水空腔的每个单体和模仿了可变长度的聚乙二醇低聚物。表面的拓扑和比较物理化学性质的道c 1和Bet v 1透露,他们可能有一些,但不是全部,共同的抗原表位。观察,大多数carrot-allergic病人Bet v 1可交叉反应的免疫球蛋白抗体,而其他人则道c这个例子不承认Bet v 1 IgE抗体。

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《Acta crystallographica.Section D. Biological crystallography》 |2009年第11期|1206-1212|共7页
作者
Zora Markovic Housley; Arnaud Basle; Sivaraman PadavattanBernhard MadereggerTilman SchirmerKarin Hoffmann Sommergruber;
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作者单位

Core Program of Structural Biology and Biophysics, Biozentrum, University of Basel, CH-4056 Basel, Switzerl;

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正文语种英语
中图分类化学;
关键词
Allergens; PFDN4 gene; carrotElectron densityCross ReactionsImmunoglobulin E;

机译：过敏原;PFDN4基因;carrotElectron densityCrossReactionsImmunoglobulin和;

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Structure of the major carrot allergen Dau c 1

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