1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells

Kausik Chattopadhyay; Udupi A. Ramagopal; Stanley G. Nathenson

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1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells

机译：1.8小鼠GITR配体二聚物的结构在果蝇S2细胞表达

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Glucocorticoid-induced TNF receptor ligand (GITRL), a prominent member of the TNF superfamily, activates its receptor on both effector and regulatory T cells to generate critical costimulatory signals that have been implicated in a wide range of T-cell immune functions. The crystal structures of murine and human orthologs of GITRL recombinantly expressed in Escherichia coli have previously been determined. In contrast to all classical TNF structures, including the human GITRL structure, murine GITRL demonstrated a unique 'strand-exchanged' dimeric organization.

机译：激素性肿瘤坏死因子受体配体(GITRL)、肿瘤坏死因子的重要成员总科,激活受体效应和调节性T细胞生成关键costimulatory信号涉及范围广泛的t细胞免疫功能。人类直接同源GITRL重组表达此前在大肠杆菌确定。结构,包括人类GITRL结构,小鼠GITRL演示了一个独一无二的“strand-exchanged”二聚的组织。

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《Acta crystallographica.Section D. Biological crystallography》 |2009年第5期|434-439|共6页
作者
Kausik Chattopadhyay; Udupi A. Ramagopal; Stanley G. Nathenson;
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作者单位

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA;

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原文格式 PDF
正文语种英语
中图分类化学;
关键词
Muridae; Murinae; Drosophila melanogasterTNFSF18 geneRegulatory T-Lymphocytes;

机译：geneRegulatory t淋巴球;

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5. 1.8 Å structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells [O] . Kausik Chattopadhyay, Udupi A. Ramagopal, Stanley G. Nathenson, -1

机译：在果蝇S2细胞中表达的小鼠GITR配体二聚体的1.8Å结构
6. 1.8 Å structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells [O] . Chattopadhyay, Kausik, Ramagopal, Udupi A., Nathenson, Stanley G., 2009

机译：在果蝇S2细胞中表达的小鼠GITR配体二聚体的1.8Å结构

1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells

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