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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Enhancement of anti-tumor immunity by lipoteichoic acid-related molecule isolated from OK-432, a streptococcal agent, in athymic nude mice bearing human salivary adenocarcinoma: role of natural killer cells.
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Enhancement of anti-tumor immunity by lipoteichoic acid-related molecule isolated from OK-432, a streptococcal agent, in athymic nude mice bearing human salivary adenocarcinoma: role of natural killer cells.

机译：在患有人唾液腺癌的无胸腺裸鼠中，通过从链球菌制剂OK-432中分离出的脂磷壁酸相关分子增强抗肿瘤免疫力：天然杀伤细胞的作用。

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BACKGROUND: OK-PSA, a lipoteichoic acid (LTA)-related molecule isolated from a streptococcal agent OK-432, enhances anti-tumor immunity as a potent inducer of Th1-type cytokines. Recently, we obtained the data suggesting that natural killer (NK) cells may play a significant role for OK-PSA-induced cytokine production in vitro. MATERIALS AND METHODS: We conducted the animal experiments using athymic nude mice bearing human salivary adenocarcinoma to examine the role of NK cells in OK-PSA-induced anti-tumor immunity. OK-PSA was peritumorally injected into the mice. Cytokines in the sera were analyzed by ELISA. mRNAs for cytokines were detected by RT-PCR. 51Cr release test was performed to measure killer cell activities. RESULTS: OK-PSA markedly increased the amounts of IFN-gamma, tumor necrosis factor (TNF)-alpha, interleukin (IL)-2, IL-12 and IL-18 that are generally called "Th1-type cytokines" in the sera derived from tumor-bearing nude mice, and also accelerated the killing activities of tumor-infiltrating lymphocytes as well as of draining lymph node cells. Furthermore, OK-PSA administration resulted in significant inhibition of tumor growth, but the effect of OK-PSA was almost completely inhibited by the deletion of NK cells using anti-asialo GM1 antibody. CONCLUSION: These findings strongly suggested that NK cells are closely involved in OK-PSA-mediated anti-tumor immunity.
机译：背景：OK-PSA是从链球菌制剂OK-432中分离出的脂蛋白酸（LTA）相关分子，可作为Th1型细胞因子的有效诱导剂增强抗肿瘤免疫力。最近，我们获得的数据表明，自然杀伤（NK）细胞可能在OK-PSA诱导的体外细胞因子生产中发挥重要作用。材料与方法：我们使用携带人唾液腺癌的无胸腺裸鼠进行了动物实验，以研究NK细胞在OK-PSA诱导的抗肿瘤免疫中的作用。将OK-PSA皮下注射到小鼠体内。通过ELISA分析血清中的细胞因子。通过RT-PCR检测细胞因子的mRNA。进行51Cr释放测试以测量杀伤细胞活性。结果：OK-PSA显着增加了血清中通常被称为“ Th1型细胞因子”的IFN-γ，肿瘤坏死因子（TNF）-α，白介素（IL）-2，IL-12和IL-18的量。来源于荷瘤裸鼠，并且还加速了肿瘤浸润淋巴细胞以及引流淋巴结细胞的杀伤活性。此外，使用OK-PSA可以显着抑制肿瘤的生长，但是使用抗亚洲人GM1抗体删除NK细胞后，OK-PSA的作用几乎被完全抑制了。结论：这些发现强烈提示NK细胞与OK-PSA介导的抗肿瘤免疫密切相关。

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