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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Significant association of cyclin D1 single nucleotide polymorphisms with oral cancer in taiwan.
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Significant association of cyclin D1 single nucleotide polymorphisms with oral cancer in taiwan.

机译：台湾细胞周期蛋白D1单核苷酸多态性与口腔癌的显着相关性。

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摘要

The cell cycle regulator cyclin D1 (CCND1) is thought to play a major role in the transition of the cell cycle from G(1) to S-phase. It is known that cancer cells have unbalanced cell cycle regulation. This study aimed to investigate the association of CCND1 single nucleotide polymorphisms A870G (rs9344) and C1722G (rs678653) with oral cancer risk and examine the interaction between CCND1 and smoking habit. MATERIALS AND METHODS: In this hospital-based case-control study, the CCND1 polymorphisms were investigated in 620 patients and 620 age- and gender-matched controls. RESULTS: Significant differences were shown between the oral cancer and control groups in the distribution of the genotypes (p=0.0014) and allelic frequency (p=0.0027) in the CCND1 rs9344 genotype. Individuals who carried at least one G allele (GG or AG) had a 0.64-fold decreased risk of developing oral cancer compared to those who carried the AA wild-type genotype (95% CI: 0.50-0.81). There was an obvious joint effect of CCND1 rs9344 genotype with smoking habit on oral cancer. CONCLUSION: Cell cycle regulation may play a role in oral carcinogenesis and CCND1 rs9344 polymorphism maybe a useful biomarker for oral oncology.
机译：细胞周期调节剂细胞周期蛋白D1（CCND1）被认为在细胞周期从G（1）到S期的过渡中起主要作用。已知癌细胞具有不平衡的细胞周期调控。这项研究旨在调查CCND1单核苷酸多态性A870G（rs9344）和C1722G（rs678653）与口腔癌风险的关联，并研究CCND1与吸烟习惯之间的相互作用。材料与方法：在这项基于医院的病例对照研究中，对620例患者以及620个年龄和性别匹配的对照进行了CCND1多态性研究。结果：在口腔癌组和对照组之间，CCND1 rs9344基因型的基因型分布（p = 0.0014）和等位基因频率（p = 0.0027）存在显着差异。与携带AA野生型基因型的人相比，携带至少一个G等位基因（GG或AG）的人患口腔癌的风险降低了0.64倍（95％CI：0.50-0.81）。 CCND1基因rs9344基因型与吸烟习惯对口腔癌有明显的联合作用。结论：细胞周期调控可能在口腔癌变过程中起作用，CCND1 rs9344基因多态性可能是口腔肿瘤的有用生物标志物。

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