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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Trends in liver function tests: a comparison with serum tumor markers in metastatic uveal melanoma (part 2).
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Trends in liver function tests: a comparison with serum tumor markers in metastatic uveal melanoma (part 2).

机译：肝功能检查的趋势：与转移性葡萄膜黑色素瘤的血清肿瘤标志物进行比较（第2部分）。

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AIM: To compare trends in liver function test (LFT) levels over consecutive visits before detection of liver metastasis (LM) from uveal melanoma (UM) with such trends in the serum tumor markers S-100beta, melanoma inhibitory activity (MIA), osteopontin (OPN), and tissue polypeptide-specific antigen (TPS). PATIENTS AND METHODS: Blood was drawn from 32 patients with metastatic UM and 43 disease-free (DF) patients semi-annually for levels of S-100beta, MIA, OPN, and TPS. Abdominal ultrasonography (US) and LFTs were used to detect LM. Median LFT levels were calculated at 6-month intervals prior to the clinical detection of LM. Trends in LFT levels over consecutive visits in the groups were compared with trends in the tumor markers for these groups. RESULTS: Only LDH gave a statistically significant difference between the trends of the metastasis and DF groups (p=0.0041). When calculating the lead time, all of the elevations were non-significant except for gamma glutamyltransferase which showed a statistically significant elevation at time 0, the time of detection of metastasis. LDH showed a rise at 0-6 months before detection, but this was not significant. For the tumor markers, steeper trendlines were shown for the metastasis group for MIA and S-100beta, and most of the markers showed a lead time of more than six months, although this was statistically significant only for OPN. CONCLUSION: Following the dynamics of tumor markers and LFTs may help to find metastatic disease in UM patients before the metastases are detectable by imaging, enabling earlier treatment.
机译：目的：比较在检测葡萄膜黑色素瘤（UM）的肝转移（LM）之前连续访问的肝功能测试（LFT）水平的趋势与血清肿瘤标志物S-100beta，黑色素瘤抑制活性（MIA），骨桥蛋白的趋势（OPN）和组织多肽特异性抗原（TPS）。患者与方法：每半年从32例转移性UM患者和43例无病（DF）患者中抽取血液，测定其S-100beta，MIA，OPN和TPS的水平。腹部超声检查（US）和LFT用于检测LM。在检测出LM之前每6个月计算一次LFT中值。将各组连续探访中LFT水平的趋势与这些组中肿瘤标志物的趋势进行比较。结果：仅LDH在转移趋势和DF组之间具有统计学上的显着差异（p = 0.0041）。在计算提前期时，除γ-谷氨酰转移酶在检测到转移的时间0时具有统计学显着性升高外，所有升高均无统计学意义。 LDH在检出前0-6个月呈上升趋势，但这并不明显。对于肿瘤标志物，MIA和S-100beta转移组的趋势线更陡峭，大多数标志物的交货期超过六个月，尽管这仅对OPN具有统计学意义。结论：跟随肿瘤标志物和LFTs的动态变化，可能有助于在UM患者中发现转移性疾病，然后才能通过影像学检查发现转移，从而实现早期治疗。

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