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首页> 外文期刊>Archives of Neurology >Vitamin E and cognitive decline in older persons.
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Vitamin E and cognitive decline in older persons.

机译：维生素E和老年人认知能力的下降。

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BACKGROUND: Previous studies raise the possibility that antioxidants protect against neurodegenerative diseases. OBJECTIVE: To examine whether intake of antioxidant nutrients, including vitamin E, vitamin C, and carotene, is associated with reduced cognitive decline with age. DESIGN: Longitudinal population-based study conducted from September 17, 1993, to November 20, 2000, with an average follow-up of 3.2 years. PATIENTS: The patients were 2889 community residents, aged 65 to 102 years, who completed a food frequency questionnaire, on average 18 months after baseline. MAIN OUTCOME MEASURE: Cognitive change as measured by 4 tests (the East Boston Memory Test, which tests immediate and delayed recall; the Mini-Mental State Examination; and the Symbol Digit Modalities Test) at baseline and 3 years for all participants, and at 6 months for 288 randomly selected participants. RESULTS: We used random-effects models to estimate nutrient effects on individual change in the average score of the 4 cognitive tests. The cognitive score declined on average by 5.0 x 10(-2) standardized units per year. There was a 36% reduction in the rate of decline among persons in the highest quintile of total vitamin E intake (-4.3 x 10(-2) standardized units per year) compared with those in the lowest quintile (-6.7 x 10(-2) standardized units per year) (P =.05), in a model adjusted for age, race, sex, educational level, current smoking, alcohol consumption, total calorie (energy) intake, and total intakes of vitamin C, carotene, and vitamin A. We also observed a reduced decline with higher vitamin E intake from foods (P =.03 for trend). There was little evidence of association with vitamin C or carotene intake. CONCLUSION: Vitamin E intake, from foods or supplements, is associated with less cognitive decline with age.
机译：背景:以往的研究提高的可能性,抗氧化剂预防神经退行性疾病。是否摄入抗氧化营养素,包括维生素E、维生素C和胡萝卜素与降低认知能力下降有关的年龄。从9月17日进行的,1993年11月2000,平均随访3.2年。病人:患者2889社区居民,年龄在65年到102年,他完成了食物频率问卷,平均18个月后基线。认知改变以4测试(东直接和波士顿记忆测试,测试延迟回忆;检查;在基准测试),3年随机参与者,在288年6个月选择参与者。随机模型来估计营养对个人平均分数的变化的影响4认知测试。平均下降了5.0 x 10(2)标准化每年单位。下降速度最高的人之一五分位数的总维生素E摄入量(-4.3 x 10 (2)标准化的单位每年)相比在最低者(-6.7 x 10 (2)标准化单位每年)(P = . 05),在一个模型调整年龄、种族、性别、教育水平,目前的吸烟、饮酒、总数卡路里(能量)的摄入量,和总摄入量维生素C,胡萝卜素,维生素a。我们也观察下降减少较高的维生素E从食物中摄入(P =。几乎没有证据表明与维生素C或协会胡萝卜素的摄入量。从食物或补充剂,与相关联随着年龄的增长较少的认知能力下降。

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