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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Vitamin B2 as a tracer for intraoperative pulmonary sentinel node navigation surgery.
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Vitamin B2 as a tracer for intraoperative pulmonary sentinel node navigation surgery.

机译：维生素B2作为术中肺前哨淋巴结导航手术的示踪剂。

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BACKGROUND: We investigated whether fluorescent agents, especially vitamin B2, can act as tracers for intraoperative pulmonary sentinel node mapping. MATERIALS AND METHODS: Vitamin B2, fluorescent beads, and green fluorescent protein (GFP) were each injected into pulmonary parenchyma in 4 pigs (experiment 1). The safety of each tracer was also verified in 12 rats (experiment 2). RESULTS: Experiment 1: In all groups, the sentinel lymph node was identified in 3 out of the 4 pigs (75%). Speed of agent dispersion: vitamin B2>GFP >fluorescent beads. Level of fluorescence judged as: vitamin B2>GFP=fluorescent beads. Experiment 2: In all groups, all rats survived until sacrifice without complications. In the fluorescent beads group, the fluorescent beads remained in the blood vessels. CONCLUSION: Vitamin B2 is inexpensive, safe and easy to apply. It is anticipated that clinical application of vitamin B2 for intraoperative pulmonary sentinel node mapping will become possible.
机译：背景：我们调查了荧光剂，尤其是维生素B2是否可以作为术中肺前哨淋巴结定位的示踪剂。材料与方法：将维生素B2，荧光珠和绿色荧光蛋白（GFP）分别注入4头猪的肺实质中（实验1）。每只示踪剂的安全性也在12只大鼠中得到验证（实验2）。结果：实验1：在所有组中，在4头猪中的3头（75％）中发现了前哨淋巴结。药剂分散速度：维生素B2> GFP>荧光珠。荧光水平判断为：维生素B2> GFP =荧光珠。实验2：在所有组中，所有大鼠均存活直至死亡且无并发症。在荧光珠组中，荧光珠残留在血管中。结论：维生素B2价格便宜，安全且易于使用。预计在手术中肺前哨淋巴结测绘中维生素B2的临床应用将成为可能。

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