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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Vitamin D: potential in the prevention and treatment of lung cancer.
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Vitamin D: potential in the prevention and treatment of lung cancer.

机译：维生素D：在预防和治疗肺癌方面具有潜力。

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摘要

Vitamin D is a steroid hormone traditionally recognized for maintaining calcium and phosphorous homeostasis in the body. However, it is now widely accepted that it exerts several extraskeletal actions, including anti-tumorigenic and immunomodulatory effects in vitro and in vivo. There is now a huge interest in studying the modes of action of vitamin D in a wide range of infectious and chronic disease settings and its potential in cancer prevention and treatment is currently under detailed investigation. In relation to the lung, evidence from observational studies, animal models and in vitro cell culture suggest that vitamin D may play a beneficial role in pulmonary inflammation. In addition, an adequate vitamin D status may be important for lung cancer prevention. Furthermore, vitamin D or its analogs, alone or in combination with cytotoxics, have potential in the treatment of lung cancer. Vitamin D is converted to its active form locally in the lung, suggesting that it may play an important role in lung health. Here, we review the evidence from observational, clinical and experimental studies in relation to vitamin D and lung cancer. In addition, we discuss vitamin D resistance in lung tumors and the potential molecular mechanisms of vitamin D action in lung cancer cells.
机译：维生素D是传统上公认的维持体内钙和磷稳态的类固醇激素。但是，现在人们广泛接受它在体外和体内发挥几种骨骼外作用，包括抗肿瘤发生和免疫调节作用。现在，人们对研究维生素D在广泛的传染性和慢性病环境中的作用方式有着极大的兴趣，目前，它在癌症预防和治疗方面的潜力正在详细研究中。关于肺部，观察性研究，动物模型和体外细胞培养的证据表明，维生素D可能在肺部炎症中发挥有益作用。此外，适当的维生素D状况对于预防肺癌可能很重要。此外，维生素D或其类似物，单独或与细胞毒素组合，在治疗肺癌中具有潜力。维生素D在肺部局部转化为其活性形式，表明它可能在肺部健康中起重要作用。在这里，我们回顾了与维生素D和肺癌有关的观察，临床和实验研究的证据。此外，我们讨论了肺癌中维生素D的抗性以及肺癌细胞中维生素D作用的潜在分子机制。

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