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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Glut 1 expression in transitional cell carcinoma of the urinary bladder is associated with poor patient survival.
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Glut 1 expression in transitional cell carcinoma of the urinary bladder is associated with poor patient survival.

机译：膀胱移行细胞癌中Glut 1的表达与患者生存不良有关。

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摘要

Cancer cells show increased glucose uptake compared to normal cells. Glut1 has been shown to be expressed in many human cancers, including transitional cell carcinoma of the urinary bladder (TCCB). The aim of this study was to determine the biologic significance of Glut1 expression, as determined by immunohistochemistry, in TCCB. Using the polyclonal anti-Glut1 antibody MYM, microwave-aided antigen retrieval, and standard immunoperoxidase ABC technique, we immunostained sections of formalin-fixed and paraffin-embedded tissue from cystectomy specimens from 40 patients with TCCB, who received no adjuvant therapy. The percent of positive cancer cells was scored on a semiquantitative scale as 1) 0%, 2) 1-10%, 3) 11-25%, 4) 26-50%, 5) 5.1-75%, and 6) > 75%. Statistical analysis was performed using the Kaplan-Meier survival method, the Log rank test, and Fisher's exact test. Glut1 immunoreactivity was detected in 58% of the cases. Glut1 expression in > 10% of cancer cells was associated with worse patient survival than expression in < 10% of the cancer cells (p = 0.0064). Tumors with > 10% Glut1-positive cancer cells were more likely to be of pT2 stage or higher than tumors with < 10% Glut1-positive cells (100% vs 68%, respectively, p = 0.0109), but showed no significant difference in the incidence of nodal metastasis (p = 0.4258). Our results suggest that Glut1 expression in TCCB is a marker of aggressive biologic potential in patients undergoing cystectomy.
机译：与正常细胞相比，癌细胞显示葡萄糖摄取增加。 Glut1已显示在许多人类癌症中表达，包括膀胱移行细胞癌（TCCB）。这项研究的目的是确定通过免疫组织化学确定的TCCB中Glut1表达的生物学意义。我们使用多克隆抗Glut1抗体MYM，微波辅助抗原修复和标准免疫过氧化物酶ABC技术，对40例未接受辅助治疗的TCCB患者的膀胱切除术标本中福尔马林固定和石蜡包埋的组织切片进行了免疫染色。阳性癌细胞百分率的半定量评分为1）0％，2）1-10％，3）11-25％，4）26-50％，5）5.1-75％和6）> 75％。使用Kaplan-Meier生存方法，对数秩检验和Fisher精确检验进行统计分析。在58％的病例中检测到Glut1免疫反应性。与在<10％的癌细胞中表达相比，> 10％的癌细胞中Glut1表达与较差的患者存活率相关（p = 0.0064）。具有> 10％Glut1阳性癌细胞的肿瘤比具有<10％Glut1阳性细胞的肿瘤更可能处于pT2期或更高（分别为100％和68％，p = 0.0109），但在淋巴结转移的发生率（p = 0.4258）。我们的结果表明，TCCB中Glut1的表达是膀胱切除术患者侵袭性生物潜力的标志。

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