...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Gamma-secretase inhibitors induce erythroid differentiation in erythroid leukemia cell lines.
【24h】

Gamma-secretase inhibitors induce erythroid differentiation in erythroid leukemia cell lines.

机译：γ-分泌酶抑制剂在红系白血病细胞系中诱导红系分化。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Notch signaling regulates the fate of hematopoietic stem cells and leukemia cells. However, the role of Notch in erythroid differentiation remains unclear. MATERIALS AND METHODS: We examined the effects of three gamma-secretase inhibitors (GSI-IX, GSI-XII and GSI-XXI) that inhibit Notch signaling on the in vitro growth and differentiation of HEL and AA erythroid leukemia cell lines. RESULTS: GSI treatment induced morphologic erythroid differentiation and promoted hemoglobin production. GSI treatment suppressed short-term growth and colony formation, while treatment with GSI-XXI promoted the growth of AA cells. The degree of differentiation induced by each GSI roughly correlated with the reduction in HES1 mRNA expression. CONCLUSION: GSIs have potential uses in differentiation induction therapy for erythroid leukemia in the future. Before clinical use, in vitro sensitivity tests should be performed because the effects of GSIs are diverse depending upon the combination of leukemia cells and GSIs.
机译：背景：Notch信号调节造血干细胞和白血病细胞的命运。但是，Notch在红系分化中的作用仍不清楚。材料与方法：我们研究了三种抑制Notch信号传导的γ-分泌酶抑制剂（GSI-IX，GSI-XII和GSI-XXI）对HEL和AA红系白血病细胞系体外生长和分化的影响。结果：GSI治疗诱导形态性红细胞分化并促进血红蛋白生成。 GSI处理抑制了短期生长和集落形成，而GSI-XXI处理促进了AA细胞的生长。每个GSI诱导的分化程度与HES1 mRNA表达的下降大致相关。结论：GSIs将来可能在红细胞白血病的分化诱导治疗中使用。在临床使用之前，应进行体外敏感性测试，因为GSI的作用因白血病细胞和GSI的组合而异。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号