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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Poly-N-acetyl glucosamine gel matrix as a non-viral delivery vector for DNA-based vaccination.
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Poly-N-acetyl glucosamine gel matrix as a non-viral delivery vector for DNA-based vaccination.

机译：聚-N-乙酰氨基葡糖凝胶基质作为基于DNA的疫苗接种的非病毒载体。

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摘要

Intramuscular administration of plasmid DNA vaccines is one of the main delivery approaches that can generate antigen specific T cell responses. However, major limitations of the intramuscular delivery strategy are the low level of myocyte transfection, resulting in a minimal level of protein expression; the inability to directly target antigen presenting cells, in particular dendritic cells, which are critical for establishment of efficacious antigen-specific immune responses. Although several viral vectors have been designed to improve plasmid DNA delivery, they have limitations, including the generation of neutralizing antibodies in addition to lacking the simplicity and versatility required for universal clinical application. We have developed an inexpensive non-viral delivery vector based on the polysaccharide polymer poly-N-acetyl glucosamine with the capability to target dendritic cells. This vector is fully biocompatible, biodegradable, and nontoxic. The advantage of the application of this delivery system relative to other approaches is discussed.
机译：肌内注射质粒DNA疫苗是可产生抗原特异性T细胞反应的主要递送方法之一。然而，肌内递送策略的主要局限性是低水平的心肌细胞转染，导致最低水平的蛋白质表达。无法直接靶向抗原呈递细胞，特别是树突状细胞，这对于建立有效的抗原特异性免疫反应至关重要。尽管已经设计了几种病毒载体来改善质粒DNA的递送，但是它们缺乏局限性，除了缺乏通用临床应用所需的简单性和多功能性之外，还包括中和抗体的产生。我们已经开发了一种基于多糖聚合物聚-N-乙酰基葡糖胺的廉价非病毒递送载体，其能够靶向树突状细胞。该载体是完全生物相容的，可生物降解的且无毒的。相对于其他方法，讨论了该交付系统的应用优势。

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