...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Molecular diagnosis of MACC1 status in lung adenocarcinoma by immunohistochemical analysis.
【24h】

Molecular diagnosis of MACC1 status in lung adenocarcinoma by immunohistochemical analysis.

机译：通过免疫组织化学分析对肺腺癌MACC1状态进行分子诊断。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Recently, we reported that overexpression of metastasis-associated colon cancer-1 (MACC1) mRNA may be a useful marker for predicting postoperative recurrence in patients with lung adenocarcinoma following surgery. However, the biological significance of mRNA overexpression is difficult to determine and is not widely used because mRNA expression analysis is relatively expensive and time- and labor-intensive. On the other hand, immunohistochemical (IHC) staining is easy to perform, well-established, inexpensive, and is a useful method which can be routinely applied in solid tumor diagnosis in clinical laboratories. PATIENTS AND METHODS: Tumor specimens were collected from 197 consecutive patients who underwent a complete resection for lung adenocarcinoma from 1998 to 2007. We analyzed the MACC1 status of the primary lung adenocarcinoma by IHC analysis. RESULTS: The average postoperative observation period was 46.7 months. Forty (20.3%) of the 197 patients developed recurrences after surgery. Positive expression of MACC1 was identified in 129 (65.5%) patients. Furthermore, MACC1 IHC was positive in 33 (82.5%) out of the 40 patients and 96 (61.1%) out of the 157 patients, with and without recurrence, respectively (p=0.011). Both univariate and multivariate logistic regression models indicated that positive staining for MACC1 was an independent factor for tumor recurrence. Furthermore, positive staining for MACC1 was associated with poorer disease-free survival (DFS), according to the univariate survival analysis (p=0.080). CONCLUSION: Positive staining for MACC1 expression in resected specimens was associated with a poorer DFS. Therefore, positive staining of IHC for MACC1 may be a useful marker for predicting postoperative recurrence in patients with lung adenocarcinoma following surgery.
机译：背景：最近，我们报道转移相关的结肠癌-1（MACC1）mRNA的过表达可能是预测肺腺癌术后患者术后复发的有用标志。然而，由于mRNA表达分析相对昂贵并且费时费力，因此mRNA过表达的生物学意义难以确定并且未被广泛使用。另一方面，免疫组化（IHC）染色易于执行，建立完善，价格低廉，并且是可在临床实验室中常规用于实体瘤诊断的有用方法。患者与方法：收集了1998年至2007年间接受了肺腺癌完全切除的197例连续患者的肿瘤标本。我们通过IHC分析了原发性肺腺癌的MACC1状况。结果：术后平均观察期为46.7个月。 197例患者中有40例（20.3％）在手术后复发。在129例（65.5％）患者中鉴定出MACC1阳性表达。此外，MACC1 IHC阳性的40例患者中有33例（82.5％）和157例中的96例（61.1％）有复发，无复发（p = 0.011）。单因素和多因素logistic回归模型均表明，MACC1阳性染色是肿瘤复发的独立因素。此外，根据单变量生存分析（p = 0.080），MACC1阳性染色与较差的无病生存期（DFS）相关。结论：切除标本中MACC1表达的阳性染色与较差的DFS有关。因此，MACC1的IHC阳性染色可能是预测肺腺癌术后患者术后复发的有用标志物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号