Crystallization and preliminary crystallographic characterization of an SH3 domain from the IB1 scaffold protein.

Dar I; Bonny C; Pedersen JTGajhede MKristensen O

首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Crystallization and preliminary crystallographic characterization of an SH3 domain from the IB1 scaffold protein.

【24h】

Crystallization and preliminary crystallographic characterization of an SH3 domain from the IB1 scaffold protein.

机译：结晶和初步的晶体描述一个SH3 IB1域脚手架蛋白。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

IB1 is a mammalian scaffold protein that interacts with components of the c-Jun N-terminal kinase (JNK) signal-transduction pathway mainly via its protein-protein interaction domains. Crystallization of the key Src homology 3 (SH3) domain of IB1 has been achieved. Crystallization experiments with unmodified protein and deliberately oxidized protein have led to different crystal forms. X-ray data have been collected to 3.0 A resolution from a crystal form with rectangular prism morphology. These crystals are orthorhombic (P2(1)2(1)2(1)), with unit-cell parameters a = 45.9, b = 57.0, c = 145.5 A. These are the first crystallographic data on a scaffold molecule such as IB1 to be reported.

机译：IB1是一种哺乳动物的脚手架蛋白相互作用c-Jun n端组件的激酶(物)信号转导途径主要是通过其蛋白质相互作用域。结晶的关键Src同源性3 (SH3)IB1领域已经实现了。与未改性蛋白质和实验故意导致氧化蛋白质不同的晶体形式。从晶体形式收集到3.0一项决议用直角棱镜形态。斜方晶系的(P2(1) 2(1) 2(1)),单胞吗参数= 45.9,b = 57.0, c = 145.5。脚手架是第一个晶体数据吗分子IB1等报道。

著录项

来源
《Acta crystallographica.Section D. Biological crystallography》 |2003年第12期|2300-2302|共3页
作者
Dar I; Bonny C; Pedersen JTGajhede MKristensen O;
展开▼
作者单位

Structural Chemistry Group, Department of Medicinal Chemistry, Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100, Denmark.;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类化学;
关键词
Scaffolding Protein; molecules; Structural ProteinSH3 DomainMAPK8IP1 genecrystal outlineCrystallization;

机译：支架蛋白,分子结构ProteinSH3 DomainMAPK8IP1 genecrystaloutlineCrystallization;

相似文献

外文文献
中文文献

1. {THE} ALBUMIN-BINDING {DOMAIN} {AS} A {SCAFFOLD} {FOR} {PROTEIN} {ENGINEERING} [J] . Johan Nilvebrant, Sophia Hober Computational and Structural Biotechnology Journal . 2013,第7期

机译：{THE}绑定蛋白{DOMAIN} {AS}一个{SCAFFOLD} {FOR} {蛋白质} {ENGINEERING}
2. Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76 [J] . Harkiolaki M., Lewitzky M., Gilbert RJC.Jones EY.Bourette RP. Mouchiroud G.Sondermann H.Moarefi I.Feller SM. EMBO Journal . 2003,第11期

机译：SH3 domain-mediated结构依据高亲和性莫娜/迦得和之间的绑定slp - 76
3. A unique set of SH3–SH3 interactions controls IB1 homodimerization [O] . Ole Kristensen, Sylvie Guenat, Imran Dar, 2006

机译：一组独特的SH3–SH3相互作用控制IB1同型二聚
4. Crystallization and preliminary X-ray diffraction analysis of the N-terminal domain of human coronavirus OC43 nucleocapsid protein [O] . Chen I.J., Chou C.C., Liu C.L., 2014

机译：Crystallization and preliminary X-ray diffraction analysis of the N-terminal domain of human coronavirus OC43 nucleocapsid protein

Crystallization and preliminary crystallographic characterization of an SH3 domain from the IB1 scaffold protein.

摘要

著录项

相似文献

相关主题

期刊订阅