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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas.
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Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas.

机译：Cyclin E和cyclin A在人肝细胞癌中的表达增强。

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摘要

BACKGROUND: Disruption of the G1/S check point leads to uncontrolled cell growth, resulting in the development of cancers. MATERIALS AND METHODS: Cell cycle regulatory molecules were investigated in 33 surgically resected hepatocellular carcinoma (HCC) samples from 30 patients by Western blotting. RESULTS: Enhanced expressions of cyclin E and cyclin A were detected at frequencies of 18/33 and 26/33 in HCCs, respectively, as compared with their neighboring noncancerous tissues. The enhanced expression of cyclin E, but not that of cyclin A, correlated with hyperphosphorylation of pRb and high frequency of Ki-67-positive cells. Thus, the HCCs with enhanced cyclin E expression probably contain a relatively large number of proliferating cancer cells. CONCLUSIONS: The degree of cyclin E expression can be used as a prognostic parameter of HCC. In addition, cyclin E may become a molecular target in the treatment of HCCs.
机译：背景：G1 / S检查点的破坏导致细胞不受控制的生长，从而导致癌症的发展。材料与方法：通过蛋白质印迹法对30例患者的33例手术切除的肝细胞癌（HCC）样品中的细胞周期调节分子进行了研究。结果：与邻近的非癌组织相比，在肝癌中分别以18/33和26/33的频率检测到细胞周期蛋白E和细胞周期蛋白A的增强表达。细胞周期蛋白E的表达增强而不是细胞周期蛋白A的表达与pRb的过度磷酸化和Ki-67阳性细胞的高频率相关。因此，具有增强的细胞周期蛋白E表达的HCC可能包含相对大量的增殖癌细胞。结论：细胞周期蛋白E的表达水平可作为肝癌的预后指标。另外，细胞周期蛋白E可能成为肝癌治疗的分子靶标。

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