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首页> 外文期刊>Antimicrobial agents and chemotherapy. >In vitro inhibition of Plasmodium falciparum rosette formation by Curdlan sulfate.
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In vitro inhibition of Plasmodium falciparum rosette formation by Curdlan sulfate.

机译：硫酸库德兰在体外抑制恶性疟原虫玫瑰花结的形成。

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摘要

Spontaneous binding of infected erythrocytes to uninfected erythrocytes to form rosettes is a property of some strains of Plasmodium falciparum that is linked to severe complications of malaria. Curdlan sulfate (CRDS) is a sulfated glycoconjugate compound that is chemically similar to known rosette-inhibiting drugs such as heparin. CRDS has previously been shown to have antimalarial activity in vitro and is safe for clinical use. Here we show that CRDS at therapeutic levels (10 to 100 microg/ml) significantly reduces rosette formation in vitro in seven P. falciparum laboratory strains and in a group of 18 African clinical isolates. The strong ability to inhibit rosetting suggests that CRDS has the potential to reduce the severe complications and mortality rates from P. falciparum malaria among African children. Our data support further clinical trials of CRDS.
机译：感染的红细胞与未感染的红细胞自发结合形成玫瑰花结是恶性疟原虫某些菌株的特性，与疟疾的严重并发症有关。硫酸Curdlan（CRDS）是一种硫酸化的糖缀合物，在化学上类似于已知的抑制玫瑰花结的药物（例如肝素）。先前已证明CRDS在体外具有抗疟活性，并且对于临床使用是安全的。在这里，我们显示了在七个恶性疟原虫实验室菌株和一组18个非洲临床分离株中，治疗水平（10至100微克/毫升）的CRDS显着降低了玫瑰花结的形成。抑制玫瑰花结的强大能力表明，CRDS有潜力降低非洲儿童恶性疟原虫疟疾的严重并发症和死亡率。我们的数据支持CRDS的进一步临床试验。

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