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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Direct effects of delta opioid receptor agonists on invasion-associated activities of HCT-8/E11 colon cancer cells.
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Direct effects of delta opioid receptor agonists on invasion-associated activities of HCT-8/E11 colon cancer cells.

机译：δ阿片受体激动剂对HCT-8 / E11结肠癌细胞的侵袭相关活性的直接影响。

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摘要

BACKGROUND: Opioids and opioid receptors are an integral part of the tumour microenvironment and hence may influence tumour progression. Studies on direct effects of opioids on invasion-associated cellular activities are equivocal. We wanted to clarify these differences. MATERIALS AND METHODS: The direct effects of the delta opioid receptor (DOR) agonists [D-Pen(2), D-Pen(5)]-enkephalin (DPDPE), leu-enkephalin and [D-Ala(2), D-Leu(5)]-enkephalin (DADLE) on invasion-associated activities of HCT-8 myc-DOR and HCT-8 FLAG-DOR colon cancer cells stably overexpressing DOR were studied. RESULTS: The opioids showed a trend to stimulate invasion of single cells in collagen in one clone, while they did not influence invasion of the other clone. In other invasion assays, no effects were observed. They did not affect cell growth and homotypical cell-cell adhesion. DPDPE at 0.1 muM inhibited directional migration; the other opioids and concentrations tested were inefficient. CONCLUSION: Opioids differently influence invasion-associated cellular activities, depending on the expression level of DOR, experimental set-up, type and concentration of opioid.
机译：背景：阿片和阿片受体是肿瘤微环境的组成部分，因此可能影响肿瘤的进展。关于阿片类药物对与入侵相关的细胞活性的直接影响的研究是模棱两可的。我们想澄清这些差异。材料与方法：δ阿片受体（DOR）激动剂[D-Pen（2），D-Pen（5）]-脑啡肽（DPDPE），亮脑啡肽和[D-Ala（2），D研究了-Leu（5）]-脑啡肽（DADLE）对稳定过量表达DOR的HCT-8 myc-DOR和HCT-8 FLAG-DOR结肠癌细胞的侵袭相关活性。结果：阿片类药物显示出刺激单个克隆中胶原单细胞入侵的趋势，而它们不影响另一克隆的入侵。在其他入侵试验中，未观察到任何影响。它们不影响细胞生长和同型细胞间粘附。 DPDPE浓度为0.1μM时会抑制方向迁移;其他阿片类药物和所测试的浓度均无效。结论：阿片类药物对肿瘤侵袭相关细胞活性的影响不同，这取决于DOR的表达水平，实验装置，阿片类药物的类型和浓度。

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