...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Prognostic value of mitotic counts in breast cancer of Saudi Arabian patients.
【24h】

Prognostic value of mitotic counts in breast cancer of Saudi Arabian patients.

机译：有丝分裂计数对沙特阿拉伯患者乳腺癌的预后价值。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Quantitative methods in combination with other objective prognostic criteria can improve the evaluation of a cancer patient's prognosis, and possibly predict response to therapy. One of the important prognostic and predictive markers is the mitotic count, which has proven valuable in many aspects. In this study, the prognostic value of the mitotic count was assessed in breast cancer (BC) patients in Saudi Arabia. PATIENTS AND METHODS: The study comprised a series of 87 patients diagnosed and treated for breast cancer at the Departments of Surgery and Oncology, King Abdul-Aziz University Hospital, between 2000 and 2008. Mitotic counts were carried out using a standard laboratory microscope (objective, x 40; field diameter, 420 mum). The number of mitotic figures in 10 consecutive high-power fields (hpf) from the most cellular area of the sample gave the mitotic activity index (MAI, mitotic figures/10 hpf). The standardized mitotic index (SMI) recorded the mitotic count as the number of mitotic figures by area of the neoplastic tissue in the microscopic field, thus the number of mitoses in 10 consecutive fields was corrected for the volume fraction and field size (mitotic figures/mm(2)). RESULTS: The means of MAI and SMI of the tumors in the entire series of 87 patients were 15 mitotic figures/10 hpf (range 4-45) and 4 mitotic figures/mm(2) (range 1-9), respectively. The mitotic counts were higher in advanced stages than in early cancer (p < 0.04). The mitotic counts were significantly larger in patients with high-grade tumor (p < 0.004) and in cases with tumor metastasis (p < 0.004). The mitotic counts were also significantly larger in the recurrent cases than in non-recurrent ones (p < 0.02). CONCLUSION: The quantitatively measurable mitotic counts of cancer cell nuclei are of significant prognostic value in invasive ductal carcinoma of the breast in Saudi Arabia and the mean cut-off values of MAI and SMI can be applied as objective (quantitative) criteria to distinguish breast cancer patients into groups with favorable and less favorable prognosis.
机译：背景：定量方法与其他客观预后标准相结合可以改善对癌症患者预后的评估，并可能预测对治疗的反应。有丝分裂计数是重要的预后和预测指标之一，在许多方面已证明是有价值的。在这项研究中，对沙特阿拉伯的乳腺癌（BC）患者评估了有丝分裂计数的预后价值。患者与方法：该研究包括2000年至2008年间在阿卜杜勒·阿齐兹国王大学医院外科和肿瘤科诊断和治疗的87例乳腺癌患者。使用标准实验室显微镜对有丝分裂计数进行计数（客观，x 40;视场直径为420毫米）。从样品的细胞最多区域开始，连续10个高倍视野（hpf）中的有丝分裂图的数量给出了有丝分裂活性指数（MAI，有丝分裂图/ 10 hpf）。标准化的有丝分裂指数（SMI）将有丝分裂计数记录为显微镜视野中肿瘤组织面积中有丝分裂图的数量，因此对10个连续视野中的有丝分裂数进行了体积分数和视野大小的校正（有丝分裂图/毫米（2））。结果：在整个87例患者中，肿瘤的MAI和SMI平均值分别为15个有丝分裂图形/ 10 hpf（范围4-45）和4个有丝分裂图形/ mm（2）（范围1-9）。在晚期阶段，有丝分裂计数高于早期癌症（p <0.04）。有高度肿瘤的患者（p <0.004）和有肿瘤转移的患者（p <0.004）的有丝分裂计数明显更高。复发病例中的有丝分裂计数也显着大于非复发病例（p <0.02）。结论：在沙特阿拉伯乳腺浸润性导管癌中，可量化测量的癌细胞核有丝分裂计数对预后具有重要价值，MAI和SMI的平均临界值可作为区分乳腺癌的客观（定量）标准患者分为预后好和不良的组。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号