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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Significant association of caveolin-1 (CAV1) genotypes with prostate cancer susceptibility in Taiwan.
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Significant association of caveolin-1 (CAV1) genotypes with prostate cancer susceptibility in Taiwan.

机译：台湾的caveolin-1（CAV1）基因型与前列腺癌易感性显着相关。

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BACKGROUND: Multiple lines of evidence have implicated the Caveolin-1 (CAV1) gene in prostate cancer progression. CAV1 is located within the locus at 7q31-33 associated with prostate cancer aggressiveness, and was identified as being overexpressed in prostate tumors. Therefore, this study evaluated the relationship between the polymorphism of CAV1 and the risk of prostate cancer in Taiwan. PATIENTS AND METHODS: Two hundred and fifty patients with prostate cancer and five hundred age-matched healthy controls recruited were genotyped. RESULTS: There were significant differences between prostate cancer and control groups in the distributions of their genotypes (p = 0.0004) and allelic frequencies (p = 4.9 x 10(-5)) in the CAV1 T29107A (rs7804372) polymorphisms. CONCLUSION: This study provides evidence for the relationship of this variant of CAV1 and risk of prostate cancer which might merit further study as a genomic marker for early detection of prostate cancer.
机译：背景：多方面的证据表明Caveolin-1（CAV1）基因与前列腺癌的进展有关。 CAV1位于7q31-33与前列腺癌侵袭性相关的基因座内，并被确定在前列腺肿瘤中过表达。因此，本研究评估了台湾CAV1基因多态性与前列腺癌风险之间的关系。患者与方法：对250名前列腺癌患者和500名年龄匹配的健康对照者进行基因分型。结果：CAV1 T29107A（rs7804372）多态性在前列腺癌和对照组之间的基因型分布（p = 0.0004）和等位基因频率（p = 4.9 x 10（-5））有显着差异。结论：本研究提供了这种CAV1变异体与前列腺癌风险之间关系的证据，可能值得进一步研究作为早期检测前列腺癌的基因组标记。

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