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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Sustained aberrant localization of KL-6 mucin and beta-catenin at the invasion front of human gastric cancer cells.
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Sustained aberrant localization of KL-6 mucin and beta-catenin at the invasion front of human gastric cancer cells.

机译：KL-6粘蛋白和β-catenin在人胃癌细胞侵袭前的持续异常定位。

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摘要

AIMS: This study sought to analyze the clinicopathological significance of KL-6 mucin, a type of MUC1, in gastric cancer and its relationship to beta-catenin. PATIENTS AND METHODS: Subcellular localization of KL-6 mucin and beta-catenin in gastric cancer tissues (n = 96) was detected immunohistochemically and its clinicopathological significance was evaluated. RESULTS: Samples with localization of KL-6 mucin in the surrounding membrane and/or cytoplasm of cancer cells at the invasion front (n = 50, 52%) had a higher incidence of deeper invasion (p < 0.0001), lymphatic vessel invasion (p = 0.0003), venous invasion (p < 0.0001), lymph node metastasis (p < 0.0001) and an advanced TNM stage (p = 0.0005). Furthermore, this localization of KL-6 mucin was associated with accumulated nuclear localization of beta-catenin. CONCLUSION: In concert with aberrant localization of beta-catenin, sustained localization of KL-6 mucin in the surrounding membrane and/or cytoplasm of cancer cells at the invasion front has a significant role in cancer progression.
机译：目的：本研究旨在分析一种类型为MUC1的KL-6粘蛋白在胃癌中的临床病理学意义及其与β-连环蛋白的关系。病人和方法：免疫组化检测KL-6粘蛋白和β-catenin在胃癌组织中的亚细胞定位（n = 96），并评估其临床病理学意义。结果：在浸润前沿（n = 50，52％）的癌细胞周围膜和/或癌细胞胞质中存在KL-6粘蛋白定位的样品具有较高的深度浸润（p <0.0001），淋巴管浸润（ p = 0.0003），静脉浸润（p <0.0001），淋巴结转移（p <0.0001）和晚期TNM分期（p = 0.0005）。此外，KL-6粘蛋白的这种定位与β-catenin的累积核定位有关。结论：与β-catenin的异常定位相一致，KL-6粘蛋白在癌细胞侵袭前沿的周围膜和/或细胞质中的持续定位在癌症进展中具有重要作用。

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