Structure of FKBP12.6 in complex with rapamycin

Champion C. S. Deivanayagam; Mike Carson; Aruna ThotakuraSthanam V. L. NarayanaRamarao S. Chodavarapu

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Structure of FKBP12.6 in complex with rapamycin

机译：与雷帕霉素FKBP12.6结构复杂

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FKBP12.6 is a novel isoform of FKBP12, which selectively binds to the cardiac ryanodine receptor (RyR2). The crystal structure of FKBP12.6 in complex with rapamycin has now been determined at 2.0 A resolution. The structures of FKBP12.6 and FKBP12 are nearly identical, except for a displacement observed in the helical region of FKBP12.6 toward the hydrophobic pocket. This displacement was not predicted by homology modeling studies. Analyses of the residues that are likely to confer the RyR2-binding specificity are presented.

机译：FKBP12.6 FKBP12的小说对碘氧基苯甲醚,选择性地结合心脏利阿诺定受体(RyR2)。FKBP12.6与雷帕霉素已经复杂2.0决议决定。FKBP12.6和FKBP12几乎是相同的,除了螺旋地区位移观测FKBP12.6向疏水口袋里。位移预测的同源性建模研究。可能会带来RyR2-binding特异性提出了。

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《Acta crystallographica.Section D. Biological crystallography》 |2000年第3期|266-271|共6页
作者
Champion C. S. Deivanayagam; Mike Carson; Aruna ThotakuraSthanam V. L. NarayanaRamarao S. Chodavarapu;
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Center for Macromolecular Crystallography, School of Optometry, 250 BHSB, 1918 University Boulevard, Birmingham, AL 35294-0005, USA;

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正文语种英语
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Dislocated Workers; Residues; crystal structureSirolimusTacrolimus Binding Protein 1AIdenticalRyanodine Receptor Calcium Release ChannelRyanodine Receptor 2;

机译：下岗工人;残留;晶体structureSirolimusTacrolimus结合蛋白1 aidenticalryanodine受体钙释放ChannelRyanodine受体2;

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Structure of FKBP12.6 in complex with rapamycin

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