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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Heterogeneity of primary site biopsies in head and neck squamous cell carcinoma.
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Heterogeneity of primary site biopsies in head and neck squamous cell carcinoma.

机译：头颈部鳞状细胞癌原发部位活检的异质性。

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AIM: There is no common standard defining how biopsies for translational research purposes should be performed. In our study, the impact of two different biopsy methods on the results of immunohistochemical staining of the samples for epidermal growth factor receptor (EGFR) and the proliferation antigen Ki-67 were evaluated. PATIENTS AND METHODS: Twenty-four patients who underwent surgical treatment of their HNSCC tumour were included. From each surgically resected tumour, one superficial biopsy and one core-needle biopsy through the cross-section of the tumour were taken. As a positive control, a tissue slide through the primary tumour was made. RESULTS: The analysis showed that neither the superficial nor the core biopsy expression of EGFR correlated significantly with that of the tumour. The analysis showed that the superficial biopsy expression of Ki-67 correlated significantly with that of tumour. CONCLUSION: Translational research projects based on biopsy tissues should be using whole surgical resection specimens of a tumour.
机译：目的：目前尚无统一标准来定义应如何进行用于翻译研究的活检。在我们的研究中，评估了两种不同的活检方法对表皮生长因子受体（EGFR）和增殖抗原Ki-67样品免疫组织化学染色结果的影响。患者和方法：包括24例接受过HNSCC肿瘤手术治疗的患者。从每个手术切除的肿瘤中，通过肿瘤的横截面进行一次浅表活检和一次芯针活检。作为阳性对照，制作了穿过原发肿瘤的组织玻片。结果：分析表明，EGFR的表面和核心活检表达均与肿瘤无明显相关性。分析表明，Ki-67的表面活检表达与肿瘤的表达显着相关。结论：基于活检组织的转化研究项目应使用肿瘤的整个手术切除标本。

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