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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Anticancer and antimetastatic activities of Renieramycin M, a marine tetrahydroisoquinoline alkaloid, in human non-small cell lung cancer cells.
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Anticancer and antimetastatic activities of Renieramycin M, a marine tetrahydroisoquinoline alkaloid, in human non-small cell lung cancer cells.

机译：海洋四氢异喹啉生物碱雷尼霉素M在人非小细胞肺癌细胞中的抗癌和抗转移活性。

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摘要

BACKGROUND: Renieramycin M, has been shown to exhibit promising anticancer activity against some cancer cell lines; however, the underlying mechanism remains unknown. MATERIALS AND METHODS: Renieramycin M was isolated from the blue sponge Xestospongia sp. Anticancer and antimetastatic activities of renieramycin M were investigated in human non-small cell lung cancer cells. RESULTS: Renieramycin M treatment caused p53 activation, which subsequently down-regulated anti-apoptotic MCL-1 and BCL-2 proteins, while the level of pro-apoptotic BAX protein was not altered. The subtoxic concentrations of renieramycin M significantly decreased invasion and migration abilities of cancer cells. In addition, this compound showed a strong inhibitory effect on anchorage-independent growth of the cells. CONCLUSION: These results reveal that renieramycin M induced lung cancer cells apoptosis through p53-dependent pathway and the compound may inhibit progression and metastasis of lung cancer cells.
机译：背景：瑞尼霉素M已显示出对某些癌细胞系的有希望的抗癌活性。但是，其潜在机制仍然未知。材料与方法：从蓝色海绵Xestospongia sp。分离到了RenieramycinM。研究了雷尼霉素M在人非小细胞肺癌细胞中的抗癌和抗转移活性。结果：雷尼霉素M治疗引起p53激活，随后下调抗凋亡的MCL-1和BCL-2蛋白，而促凋亡的BAX蛋白水平未改变。瑞奈霉素M的亚毒性浓度显着降低了癌细胞的侵袭和迁移能力。另外，该化合物对细胞的锚定非依赖性生长显示出强抑制作用。结论：这些结果表明瑞尼霉素M通过p53依赖性途径诱导肺癌细胞凋亡，并且该化合物可能抑制肺癌细胞的进展和转移。

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