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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Improvement of biodistribution with PEGylated liposomes containing docetaxel with degradable starch microspheres for hepatic arterial infusion in the treatment of liver metastases: a study in CC-531 liver tumor-bearing WAG RIJ rats.
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Improvement of biodistribution with PEGylated liposomes containing docetaxel with degradable starch microspheres for hepatic arterial infusion in the treatment of liver metastases: a study in CC-531 liver tumor-bearing WAG RIJ rats.

机译：含多西紫杉醇的聚乙二醇化脂质体和可降解淀粉微球体的改进可用于肝动脉输注治疗肝转移的生物分布：在CC-531荷瘤WAG RIJ大鼠中的研究。

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AIM: To improve the drug concentration in liver metastases, docetaxel was encapsulated in polyethyleneglycol-liposomes and administered regionally with degradable starch microspheres (DSM). MATERIALS AND METHODS: A rodent model of solitary metastasis (CC-531 adenocarcinoma) was studied. The animals were randomized into six groups and treated with 15 ng/kg docetaxel: I: intravenous (i.v.). II: PEG-liposomes i.v.; III: intraartial (i.a.) via the hepatica artery; IV: i.a.) + DSM; V: PEG-liposomes i.a.; and VI: PEG-liposomes i.a. + DSM. The docetaxel concentration in the serum, liver and liver tumor at defined times (5, 15, 30, 60,120 240 min and 24 h) was measured using HPLC. RESULTS: The area under the concentration (AUC) versus time curves showed an 11-fold higher concentration in the tumor tissue when comparing the docetaxel-PEG-liposomes i.a. + DSM group to the i.v. group (p<0.01). CONCLUSION: Compared to intravenous therapy, i.a. therapy with docetaxel-PEG-liposomes + DSM results in higher tumor tissue concentrations.
机译：目的：为提高肝转移中的药物浓度，将多西紫杉醇封装在聚乙二醇脂质体中，并与可降解淀粉微球（DSM）局部给药。材料与方法：研究了孤立转移（CC-531腺癌）的啮齿动物模型。将动物随机分为六组，并用15ng / kg多西紫杉醇治疗：I：静脉内（i.v.）。 II：PEG-脂质体，i.v .; III：经由肝动脉的动脉内（i.a.）; IV：i.a。）+ DSM; V：PEG-脂质体。和VI：PEG脂质体+ DSM。使用HPLC测量在确定的时间（5、15、30、60、120、240分钟和24小时）的血清，肝和肝肿瘤中多西紫杉醇的浓度。结果：当比较多西他赛-PEG-脂质体即肿瘤时，浓度下的面积（AUC）与时间的关系曲线显示肿瘤组织中的浓度高11倍。 + DSM小组加入i.v.组（p <0.01）。结论：与静脉内治疗相比，即多西他赛-PEG-脂质体+ DSM联合治疗可导致更高的肿瘤组织浓度。

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