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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Aberrant methylation of the Vimentin gene in hepatocellular carcinoma.
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Aberrant methylation of the Vimentin gene in hepatocellular carcinoma.

机译：肝细胞癌中波形蛋白基因的异常甲基化。

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BACKGROUND: Recently, it was shown that the Vimentin gene, usually activated in mesenchymal cells, was highly methylated in colorectal carcinoma. MATERIALS AND METHODS: The methylation status of the Vimentin gene was examined in primary carcinomas and the corresponding normal tissues derived from 43 patients with hepatocellular carcinoma (HCC) using quantitative methylation-specific PCR (qMSP) and the correlation between the methylation status and the clinicopathological findings was evaluated. RESULTS: Aberrant methylation of the Vimentin gene was detected in 24 out of the 43 (56%) primary HCC. This result suggested that the aberrant methylation of the Vimentin gene was frequent in HCC. Subsequently, clinicopathological data were correlated with the methylation status. A significant difference was observed in the value of alpha-fetoprotein (AFP) (p=0.045), maximal tumor size (p=0.048) and TNM stage (p=0.043) between the methylation-positive and -negative cases. CONCLUSION: Aberrant methylation of Vimetin might be an early event in the course of hepatocarcinogenesis.
机译：背景：最近发现，通常在间充质细胞中激活的波形蛋白基因在大肠癌中高度甲基化。材料与方法：使用定量甲基化特异性PCR（qMSP）检测了43例肝细胞癌（HCC）的原发癌和相应的正常组织中波形蛋白基因的甲基化状态，并检测了甲基化状态与临床病理评估结果。结果：在43例（56％）原发性肝癌中，有24例检测到波形蛋白基因异常甲基化。该结果表明，波形蛋白基因的异常甲基化在HCC中是频繁的。随后，临床病理数据与甲基化状态相关。在甲基化阳性和阴性病例之间，甲胎蛋白（AFP）（p = 0.045），最大肿瘤大小（p = 0.048）和TNM分期（p = 0.043）的值存在显着差异。结论：Vimetin甲基化异常可能是肝癌发生过程中的早期事件。

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