Structural studies of the Msx-1 homeodomain-DNA complex I.

DeWees S; Geiger JH

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Structural studies of the Msx-1 homeodomain-DNA complex I.

机译：结构的研究Msx-1 homeodomain-DNA复杂的我。

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Crystals of the Msx-1 homeodomain-DNA complex have been obtained by hanging-drop vapor diffusion at 293 K in 12% PEG 4000 and 0.1 M sodium acetate pH 4.6. The homeodomain consists of 60 amino acids and is the DNA-binding domain. The DNA in the complex was 16 base pairs with the sequence 5'-TGTCACTAATTGAAGG-3', containing an overhang T at each end. The crystals diffract to 2.15 A (99.8% completeness) using cryogenic (123 K) conditions. The crystals belong to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a = 33.66, b = 60.96, c = 83.37 A. The structure will illuminate the details of Msx-1-DNA binding specificity and clarify its role in transcriptional regulation. Mutations in Msx-1 cause craniofacial deformities in mice.

机译：晶体的Msx-1 homeodomain-DNA复杂获得了悬滴蒸汽扩散4000年12% PEG 293 K和0.1醋酸钠的pH值4.6. dna结合域。复杂的是16个碱基对序列5 ' -TGTCACTAATTGAAGG-3’,包含一个过剩T在每个结束。完整性(99.8%)使用低温(123 K)条件。斜方晶系的空间群P2 (1) 2 (1) 2 (1)晶胞参数= 33.66,b = 60.96, c =83.37。Msx-1-DNA绑定特异性和细节阐明它在转录调控中的作用。突变Msx-1引起颅面畸形在老鼠身上。

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《Acta crystallographica.Section D. Biological crystallography》 |1999年第12期|2039-2040|共2页
作者
DeWees S; Geiger JH;
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Michigan State University Chemistry Department, East Lansing, MI 48824, USA.;

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正文语种英语
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Crystallography; crystals; MutationSTRUCTURAL STUDYAnimalsBase SequenceX-rays;

机译：结晶学;晶体;MutationSTRUCTURALSTUDYAnimalsBase SequenceX-rays;

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Structural studies of the Msx-1 homeodomain-DNA complex I.

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