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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >C-myc amplification and cluster analysis in human gastric carcinoma.
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C-myc amplification and cluster analysis in human gastric carcinoma.

机译：人胃癌中的C-myc扩增和聚类分析。

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The tumour samples ot 23 patients (9 male, 14 female, aged 28-85) were randomly selected for the study. DNA was isolated from paraffin embedded tissue for quantitative dot-blot hybridization, in order to determine the amplification values for the c-myc and K-ras oncogenes. The clinical and histological parameters studied were as follows: grade, TNM staging system, Lauren's histological type, localization and the severity of the disease. Amplified c-myc was found in 6 cases. Amplification was concomitant with c-myc overexpression detected with immunohistochemical staining. The amplification--9.1-fold on the average (ranging from 2.12 to 18.2) was significantly associated with the presence of distant metastasis (corr. coeff.: 0.5623, p < 0.01), but with none of the other parameters. No case with K-ras amplification was recorded. The result of the multivariate cluster analysis proved that age was the decisive factor in the segregation process. This age-related distribution (69 vs. 40, p < 0.001), however, did not coincide with either the incidence of distant metastasis or c-myc amplification.
机译：随机选择23例患者的肿瘤样本（男9例，女14例，年龄28-85）。从石蜡包埋的组织中分离DNA进行定量斑点杂交，以确定c-myc和K-ras癌基因的扩增值。研究的临床和组织学参数如下：等级，TNM分期系统，Lauren的组织学类型，定位和疾病的严重程度。在6例中发现了扩增的c-myc。扩增伴随着免疫组织化学染色检测到的c-myc过表达。平均扩增-9.1倍（2.12至18.2）与远处转移的存在显着相关（校正系数：0.5623，p <0.01），但没有其他参数。没有记录到K-ras扩增的病例。多元聚类分析的结果证明，年龄是隔离过程中的决定性因素。然而，这种与年龄相关的分布（69 vs. 40，p <0.001）与远处转移或c-myc扩增的发生均不符。

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