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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Salicylate Reduces Susceptibility of Mycobacterium tuberculosis to Multiple Antituberculosis Drugs.
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Salicylate Reduces Susceptibility of Mycobacterium tuberculosis to Multiple Antituberculosis Drugs.

机译：水杨酸盐降低了结核分枝杆菌对多种抗结核药物的敏感性。

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摘要

Salicylate induces multiple antibiotic resistance in various bacterial species. Here we investigated the effect of salicylate on the susceptibility of Mycobacterium tuberculosis to a range of antituberculosis (anti-TB) drugs. In the presence of salicylate, the killing effects of isoniazid (INH), rifampin (RMP), ethambutol (EMB), streptomycin (STR), and p-aminosalicylate (PAS) were reduced, as shown with a tetrazolium redox dye viability assay and a bacterial survival assay. Salicylate-induced resistance was more pronounced for PAS, STR, and EMB but was not apparent for INH and RMP when salicylate and the anti-TB agents were incorporated into 7H11 plates. The significance of these findings for TB treatment needs to be further evaluated in vivo.
机译：水杨酸盐在多种细菌种类中诱导多种抗生素抗性。在这里，我们研究了水杨酸盐对结核分枝杆菌对一系列抗结核药（抗结核病）药物敏感性的影响。在水杨酸酯存在下，异烟肼（INH），利福平（RMP），乙胺丁醇（EMB），链霉素（STR）和对氨基水杨酸酯（PAS）的杀伤作用减弱，如四唑氧化还原染料活力测定和细菌存活率测定。当将水杨酸酯和抗结核剂掺入7H11平板中时，水杨酸酯诱导的耐药性对于PAS，STR和EMB更为明显，但对于INH和RMP则不明显。这些发现对于结核病治疗的意义需要在体内进一步评估。

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