Association of a Novel Human Immunodeficiency Virus Type 1 Protease Substrate Cleft Mutation, L23I, with Protease Inhibitor Therapy and In Vitro Drug Resistance.

Johnston E; Winters MA; Rhee SY; Merigan TC; Schiffer CA; Shafer RW

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Association of a Novel Human Immunodeficiency Virus Type 1 Protease Substrate Cleft Mutation, L23I, with Protease Inhibitor Therapy and In Vitro Drug Resistance.

机译：新型人类免疫缺陷病毒1型蛋白酶底物裂口突变L23I与蛋白酶抑制剂治疗和体外耐药性的关联。

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We observed a previously uncharacterized mutation in the protease substrate cleft, L23I, in 31 of 4,303 persons undergoing human immunodeficiency virus type 1 genotypic resistance testing. In combination with V82I, L23I was associated with a sevenfold reduction in nelfinavir susceptibility and a decrease in replication capacity. In combination with other drug resistance mutations, L23I was associated with multidrug resistance and a compensatory increase in replication capacity.

机译：我们在接受人类免疫缺陷病毒1型基因型耐药性测试的4,303人中的31人中观察到了蛋白酶底物裂口L23I中先前未鉴定的突变。与V82I组合使用时，L23I可使奈非那韦敏感性降低7倍，复制能力降低。结合其他耐药突变，L23I与多药耐药和复制能力的补偿性增加相关。

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《Antimicrobial agents and chemotherapy.》 |2004年第12期|共5页
作者
Johnston E; Winters MA; Rhee SY; Merigan TC; Schiffer CA; Shafer RW;
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正文语种 eng
中图分类药学;
关键词
Endopeptidases; Mutation; Drug Resistance; replication; Therapeutic procedure; 突变; 抗药性;

机译：Endopeptidases;Mutation;Drug Resistance;replication;Therapeutic procedure;突变;抗药性;

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1. Association of a Novel Human Immunodeficiency Virus Type 1 Protease Substrate Cleft Mutation, L23I, with Protease Inhibitor Therapy and In Vitro Drug Resistance. [J] . Johnston E, Winters MA, Rhee SY, Antimicrobial agents and chemotherapy. . 2004,第12期

机译：新型人类免疫缺陷病毒1型蛋白酶底物裂口突变L23I与蛋白酶抑制剂治疗和体外耐药性的关联。
2. Secondary mutations in the protease region of human immunodeficiency virus and virologic failure in drug-naive patients treated with protease inhibitor-based therapy. [J] . Perno CF, Cozzi-Lepri A, Balotta C, The Journal of Infectious Diseases . 2001,第8期

机译：人类免疫缺陷病毒蛋白酶区域的继发突变和未经蛋白酶治疗的初治患者的病毒学衰竭。
3. Effect of point mutations on the kinetics and the inhibition of human immunodeficiency virus type 1 protease: relationship to drug resistance. [J] . Lin Y, Lin X, Hong L, Biochemistry . 1995,第4期

机译：点突变对动力学和人类免疫缺陷病毒1型蛋白酶的抑制作用的影响：与耐药性的关系。
4. Susceptibility to a non-conventional (folding) protease inhibitor of human immunodeficiency virus Type 1 isolates in vitro [C] . S. RUSCONI, M. Lo CICERO, S. FERRAMOSCA, International School of Physics "Enrico Fermi" . 2007

机译：对人免疫缺陷病毒的非常规（折叠）蛋白酶抑制剂的易感性在体外1型分离物
5. Drug resistance mechanisms and drug design strategies for human immunodeficiency virus and hepatitis C virus proteases [D] . Wang, Yong 2012

机译：人类免疫缺陷病毒和丙型肝炎病毒蛋白酶的耐药机制和药物设计策略
6. Association of a Novel Human Immunodeficiency Virus Type 1 Protease Substrate Cleft Mutation L23I with Protease Inhibitor Therapy and In Vitro Drug Resistance [O] . Elizabeth Johnston, Mark A. Winters, Soo-Yon Rhee, 2004

机译：新型人类免疫缺陷病毒1型蛋白酶底物裂口突变L23I与蛋白酶抑制剂治疗和体外耐药性的关联
7. Association of a Novel Human Immunodeficiency Virus Type 1 Protease Substrate Cleft Mutation, L23I, with Protease Inhibitor Therapy and In Vitro Drug Resistance [O] . Johnston, Elizabeth, Winters, Mark A., Rhee, Soo-Yon, 2004

机译：新型人类免疫缺陷病毒1型蛋白酶底物裂口突变L23I与蛋白酶抑制剂治疗和体外耐药性的关联

Association of a Novel Human Immunodeficiency Virus Type 1 Protease Substrate Cleft Mutation, L23I, with Protease Inhibitor Therapy and In Vitro Drug Resistance.

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